Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation

C57BL/6(B6)-jsd/jsd mice are sterile due to the defective spermatogenesis in the testes. To know the cause of the deficient spermatogenesis in B6-jsd/jsd mice, we examined whether the problem is within or outside the seminiferous tubules by transplanting tubules from cryptorchid testes of B6- +/+ mi...

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Bibliographic Details
Published inJournal of cellular physiology Vol. 150; no. 1; p. 188
Main Authors Mizunuma, M, Dohmae, K, Tajima, Y, Koshimizu, U, Watanabe, D, Nishimune, Y
Format Journal Article
LanguageEnglish
Published United States 01.01.1992
Subjects
Animals
Cell Differentiation
Cryptorchidism - genetics
Cryptorchidism - pathology
Male
Mice
Mice, Inbred C57BL
Mutation
Seminiferous Tubules - transplantation
Spermatogenesis - genetics
Spermatogonia - pathology
Spermatozoa - pathology
Testis - surgery
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Summary:C57BL/6(B6)-jsd/jsd mice are sterile due to the defective spermatogenesis in the testes. To know the cause of the deficient spermatogenesis in B6-jsd/jsd mice, we examined whether the problem is within or outside the seminiferous tubules by transplanting tubules from cryptorchid testes of B6- +/+ mice into B6-jsd/jsd testes or tubules from B6-jsd/jsd mice into testes of (WB x C57BL/6)F1-W/Wv (hereafter, WBB6F1-W/Wv) mice. Type A spermatogonia differentiated into spermatids in seminiferous tubules from cryptorchid testes transplanted into B6-jsd/jsd testes. In contrast, in B6-jsd/jsd tubules transplanted into WBB6F1-W/Wv testes, type A spermatogonia were stimulated to mitotic proliferation, but didn't proceed to any differentiated germ cells. The present results suggest that the cause of the deficient spermatogenesis in B6-jsd/jsd mice is a defect of intratubular environment to support germ cell differentiation.
ISSN:0021-9541
DOI:10.1002/jcp.1041500125