Yb-DTPA, a novel contrast agent in magnetic resonance imaging: application to rat kidney

We have developed a novel contrast agent, ytterbium-diethylenetriamine pentaacetic acid (Yb-DTPA), for magnetic resonance imaging (MRI) and its mechanism of action is predominantly by the susceptibility mechanism. We have applied this contrast agent for renal MRI studies. We also demonstrate that Yb...

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Bibliographic Details
Published inMagnetic resonance in medicine Vol. 17; no. 2; p. 328
Main Authors Sarkar, S K, Rycyna, R E, Lenkinski, R E, Solleveld, H A, Kinter, L B
Format Journal Article
LanguageEnglish
Published United States 01.02.1991
Subjects
Animals
Contrast Media - chemical synthesis
Gadolinium
Gadolinium DTPA
Glomerular Filtration Rate
Image Enhancement - methods
Inulin - pharmacokinetics
Kidney - anatomy & histology
Kidney - metabolism
Kidney Medulla - anatomy & histology
Magnetic Resonance Imaging - methods
Male
Organometallic Compounds
Pentetic Acid - pharmacokinetics
Rats
Rats, Inbred Strains
Ytterbium - pharmacokinetics
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Summary:We have developed a novel contrast agent, ytterbium-diethylenetriamine pentaacetic acid (Yb-DTPA), for magnetic resonance imaging (MRI) and its mechanism of action is predominantly by the susceptibility mechanism. We have applied this contrast agent for renal MRI studies. We also demonstrate that Yb-DTPA has a renal clearance similar to that of inulin in rats and may therefore be useful for the estimation of glomerular filtration rate.
ISSN:0740-3194
DOI:10.1002/mrm.1910170205