Successful Treatment of Pegaspargase-Induced Acute Hepatotoxicity with Vitamin B Complex and L-Carnitine

Pegaspargase is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL). One of the adverse effects of pegaspargase is hepatotoxicity, which can rapidly lead to liver failure and death. We report a patient with ALL who developed pegaspargase-induced severe hepatotoxicity that...

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Bibliographic Details
Published inProceedings - Baylor University. Medical Center Vol. 29; no. 1; pp. 46 - 47
Main Authors Lu, Gary, Karur, Vinit, Herrington, Jon D., Walker, Mary G.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2016
Taylor & Francis Group LLC
Taylor & Francis Ltd
Baylor Health Care System
Subjects
Care and treatment
Case reports
Case Studies
Dosage and administration
Levocarnitine
Liver
Liver diseases
Patient outcomes
Toxicity
Vitamin B
Vitamin B complex
United States
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Summary:Pegaspargase is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL). One of the adverse effects of pegaspargase is hepatotoxicity, which can rapidly lead to liver failure and death. We report a patient with ALL who developed pegaspargase-induced severe hepatotoxicity that was rescued by treatment with vitamin B complex and L-carnitine. Our patient had a quicker response than prior reported cases, suggesting this treatment might be a better regimen.
ISSN:0899-8280
1525-3252
DOI:10.1080/08998280.2016.11929355