Mammalian hyaluronan synthases

Three mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size. The expression of eac...

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Bibliographic Details
Published inIUBMB life Vol. 54; no. 4; p. 195
Main Authors Itano, Naoki, Kimata, Koji
Format Journal Article
LanguageEnglish
Published England 01.10.2002
Subjects
Animals
Glucuronosyltransferase - genetics
Glycosyltransferases
Hyaluronan Synthases
Hyaluronic Acid - biosynthesis
Isoenzymes - genetics
Membrane Proteins
Transferases
Xenopus Proteins
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Summary:Three mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size. The expression of each HAS isoform is controlled in a different fashion when mammalian cells are stimulated by various cytokines and the expression patterns are both spatially and temporally regulated during embryonic development. The existence of three different HAS isoforms with different characteristics implies that the broad range of biological and physiological roles performed by HA are regulated by controlling the activities and expression of the HAS isoforms. This review focuses on recent findings on the regulatory mechanisms for controlling HA biosynthesis and provides new insights into the enzymic basis for the functional regulation of HA.
ISSN:1521-6543
DOI:10.1080/15216540214929