Renal imaging studies at 1.5 and 9.4 T: effects of diuretics

We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has l...

Full description

Saved in:
Bibliographic Details
Published inMagnetic resonance in medicine Vol. 7; no. 1; p. 117
Main Authors Sarkar, S K, Holland, G A, Lenkinski, R E, Mattingly, M A, Kinter, L B
Format Journal Article
LanguageEnglish
Published United States 01.05.1988
Subjects
Animals
Arginine Vasopressin - analogs & derivatives
Arginine Vasopressin - pharmacology
Diuretics - pharmacology
Furosemide - pharmacology
Kidney - anatomy & histology
Kidney - drug effects
Kidney Cortex - anatomy & histology
Kidney Cortex - drug effects
Kidney Medulla - anatomy & histology
Kidney Medulla - drug effects
Magnetic Resonance Imaging
Male
Mice
Mice, Nude
Rats
Rats, Inbred Strains
Online AccessGet more information

Cover

More Information
Summary:We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has little effect. This phenomenon appears to be related to changes in luminal water content. We also demonstrate the feasibility of obtaining live mouse kidney images with a resolution of 100 x 100 x 700 micrometers at 9.4 T.
ISSN:0740-3194
DOI:10.1002/mrm.1910070114