A double-blind evaluation of the nocturnal antisecretory effects of anisotropine methylbromide in man. Dose response and duration of action studies

• Published in: Journal of clinical pharmacology Vol. 17; no. 1; p. 29
• Main Authors: Freston, J W, Forbes, J A
• Format: Journal Article
• Language: English
• Published: England 01.01.1977
• Subjects: Adult; Clinical Trials as Topic; Depression, Chemical; Dose-Response Relationship, Drug; Fasting; Gastric Juice - metabolism; Humans; Hydrogen-Ion Concentration; Male; Placebos; Time Factors; Tropanes - administration & dosage; Tropanes - adverse effects; Tropanes - pharmacology
• ISSN: 0091-2700
• DOI: 10.1002/j.1552-4604.1977.tb04583.x

The effects of graded doses of anisotropine methylbromide on nocturanl gastric secretion were investigated in a double-blind crossover study in man. Single doses considerably higher than those usually employed for daytime use in adjunctive therapy of peptic ulcer disease significantly reduced acid secretion without significantly influencing heart rate, blood pressure, visual acuity, or visual accommodation. The duration of action of large doses was then evaluated in fasted and nonfasted subjects. A single dose reduced acid secretion for up to 8 hours, eliminating the nocturnal elevation of acid secretion characteristic of the normal circadian pattern. Near visual acuity and accommodation decreased, an effect more pronounced in fasted subjects, but the magnitude of visual impairment was small. These findings provide the basis for a controlled trial of high-dose nighttime therapy in peptic ulcer disease.