Association of accelerated switch from vertebral end‐plate Modic I to Modic 0 signal changes with clinical benefit of intradiscal corticosteroid injection for chronic low back pain

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 63; no. 9; pp. 2828 - 2831
• Main Authors: Nguyen, Christelle, Bénichou, Marc, Revel, Michel, Poiraudeau, Serge, Rannou, François
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2011; Wiley; Wiley Subscription Services, Inc
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; Back pain; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chronic Disease; Diseases of the osteoarticular system; Diseases of the spine; Humans; Intervertebral Disc - diagnostic imaging; Intervertebral Disc - drug effects; Intervertebral Disc - pathology; Low Back Pain - diagnostic imaging; Low Back Pain - drug therapy; Low Back Pain - pathology; Lumbar Vertebrae; Magnetic Resonance Imaging - methods; Male; Medical sciences; NMR; Nuclear magnetic resonance; Pharmacology. Drug treatments; R&D; Radiography; Research & development; Treatment Outcome; Corticosteroid; Chronic; Pain; Lumbar spine; Low back pain; Diseases of the osteoarticular system; Rheumatology; Rachialgia; Vertebra; Spine disease
• ISSN: 0004-3591; 2326-5191; 1529-0131; 2326-5205
• DOI: 10.1002/art.30443

Modic I vertebral end‐plate signal changes detected by magnetic resonance imaging (MRI) are associated with chronic low back pain. Typically, Modic I signal changes in untreated patients switch to non–Modic I signal changes within 3 years, which reflect spontaneous healing. Recent findings suggest that Modic I signal changes may be related to local inflammatory changes, providing a rationale for treatment with intradiscal injections of antiinflammatory drugs. In the present report, we describe a 31‐year‐old man with 1‐year history of chronic low back pain associated with vertebral end‐plate Modic I signal changes, who received 1 intradiscal corticosteroid injection in L5–S1. Local treatment led to rapid pain relief and was associated with an accelerated switch from Modic I to Modic 0 signal changes, as seen on lumbar MRI at 1‐month followup. This is the first report of an effective local treatment for both the symptoms and the structural changes of chronic low back pain that are associated with Modic I signal changes. Additionally, this case reinforces the hypothesis that local inflammation has a pathogenic role.