Severe reactions to Cuprophan capillary dialyzers

Five severe reactions occurred in four maintenance hemodialysis patients 1 to 5 minutes after initiating dialysis with Cuprophan capillary dialyzers. All reactions were life-threatening and one resulted in death. Inadequate rinsing of the dialyzers was probably the cause of the reactions. The severe...

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Bibliographic Details
Published inArtificial organs Vol. 6; no. 3; p. 312
Main Authors Popli, S, Ing, T S, Daugirdas, J T, Kheirbek, A O, Viol, G W, Vilbar, R M, Gandhi, V C
Format Journal Article
LanguageEnglish
Published United States 01.08.1982
Subjects
Anaphylaxis - chemically induced
Anaphylaxis - therapy
Cellulose - adverse effects
Cellulose - analogs & derivatives
Drug Hypersensitivity - etiology
Drug Hypersensitivity - therapy
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Male
Membranes, Artificial
Middle Aged
Renal Dialysis - adverse effects
Renal Dialysis - methods
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Summary:Five severe reactions occurred in four maintenance hemodialysis patients 1 to 5 minutes after initiating dialysis with Cuprophan capillary dialyzers. All reactions were life-threatening and one resulted in death. Inadequate rinsing of the dialyzers was probably the cause of the reactions. The severe reactions were managed by immediate discontinuation of dialysis and the institution of supportive treatment. Antianaphylactic measures were also attempted, but their therapeutic effectiveness remains to be determined.
ISSN:0160-564X
DOI:10.1111/j.1525-1594.1982.tb01679.x