Adaptive assignment versus balanced randomization in clinical trials: a decision analysis

We compare balanced randomization with four adaptive treatment allocation procedures in a clinical trial involving two treatments. The objective is to treat as many patients in and out of the trial as effectively as possible. Randomization is a satisfactory solution to the decision problem when the...

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Bibliographic Details
Published inStatistics in medicine Vol. 14; no. 3; p. 231
Main Authors Berry, D A, Eick, S G
Format Journal Article
LanguageEnglish
Published England 15.02.1995
Subjects
Controlled Clinical Trials as Topic
Decision Support Techniques
Humans
Patient Selection
Randomized Controlled Trials as Topic
Research Design
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Summary:We compare balanced randomization with four adaptive treatment allocation procedures in a clinical trial involving two treatments. The objective is to treat as many patients in and out of the trial as effectively as possible. Randomization is a satisfactory solution to the decision problem when the disease in question is at least moderately common. Adaptive procedures are more difficult to use, but might play a role in clinical research when a substantial proportion of all patients with the disease are included in the trial.
ISSN:0277-6715
DOI:10.1002/sim.4780140302