Effect of surfactants on percutaneous absorption of naproxen I: comparisons of rabbit, rat, and human excised skin

The in vitro skin penetration model using excised skin from rats, rabbits, and humans was examined to evaluate the relative effect of surfactants on percutaneous absorption of naproxen. Differences in the magnitude of the effect of surfactants in promoting percutaneous absorption of naproxen through...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 67; no. 9; p. 1272
Main Authors Chowhan, Z T, Pritchard, R
Format Journal Article
LanguageEnglish
Published United States 01.09.1978
Subjects
Animals
Humans
In Vitro Techniques
Male
Naproxen - metabolism
Pharmaceutical Vehicles
Rabbits
Rats
Skin Absorption - drug effects
Species Specificity
Surface-Active Agents - pharmacology
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Summary:The in vitro skin penetration model using excised skin from rats, rabbits, and humans was examined to evaluate the relative effect of surfactants on percutaneous absorption of naproxen. Differences in the magnitude of the effect of surfactants in promoting percutaneous absorption of naproxen through skins of different species were observed. For comparative evaluations of the formulation effects on percutaneous absorption, such as the effect of surfactants, in vitro studies with animal skin may not provide information in agreement with in vitro human skin.
ISSN:0022-3549
DOI:10.1002/jps.2600670921