Ethanol Action on Neural Networks Studied with Multineuron Recording in Freely Moving Animals

The advent of new chronic multineuron recording techniques for examining neural activity in behaving animals has initiated a new phase in the analysis of the neuronal mechanisms that underlie ethanol and other drug self‐administration. The technique allows for the simultaneous recording of groups of...

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Published inAlcoholism, clinical and experimental research Vol. 22; no. 1; pp. 10 - 22
Main Authors Woodward, Donald J., Janak, Patricia H., Chang, Jing-Yu
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.1998
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Summary:The advent of new chronic multineuron recording techniques for examining neural activity in behaving animals has initiated a new phase in the analysis of the neuronal mechanisms that underlie ethanol and other drug self‐administration. The technique allows for the simultaneous recording of groups of individual neurons in one or more brain regions during ongoing behavior; therefore, the spatiotemporal patterns of neuronal activity during specific behavioral events can be determined. We have successfully applied this technique to rat models of cocaine and heroin self‐administration. Recently, using rats, we have been able to record from neurons in areas of the mesocorticolimbic circuit during ethanol‐reinforced operant responding. In this review, we describe the current and future application of this new behavioral neurophysiology to the investigation of the neurobiology of alcohol addiction.
Bibliography:ark:/67375/WNG-32W0J5L7-0
istex:328A3A19D5B17D3762A768F22E4564A82592905F
ArticleID:ACER10
This study was supported by grants AA 10980 to D.J. W. and AA 07565 to P.H.J, and by a Tourette Syndrome Association Award to P.H.J. Technological development was supported by NSF DBI 9110308 and 99619063, and ONR N 14‐96‐1‐1104 to D.J.W.
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.1998.tb03612.x