The detection of endocervical gland involvement by high grade squamous intraepithelial lesions in smears prepared from endocervical brush specimens

• Published in: Cytopathology (Oxford) Vol. 7; no. 5; p. 310
• Main Authors: Van Hoeven, K H, Hanau, C A, Hudock, J A
• Format: Journal Article
• Language: English
• Published: England 01.10.1996
• Subjects: Cervical Intraepithelial Neoplasia - pathology; Cervix Uteri - pathology; Female; Humans; Neoplasms, Glandular and Epithelial - pathology; Uterine Cervical Neoplasms - pathology; Vaginal Smears - methods
• ISSN: 0956-5507
• DOI: 10.1111/j.1365-2303.1996.tb00309.x

The cytologic features of squamous cell carcinoma in situ with endocervical gland involvement have been described in cervical smears. We evaluated the presence of two types of cellular fragments in 43 cervical smears of high grade squamous intraepithelial lesions (HGSIL) to assess their ability to predict glandular involvement by HGSIL in subsequent cone biopsies. An endocervical brush was used to obtain all endocervical specimens. Of 16 cases without glandular involvement, fragments were present in 13 smears. Of 27 cases with glandular involvement, fragments were absent in 11 smears. No statistical association was identified between the presence of abnormal cellular fragments on cervical smears of HGSIL and endocervical gland involvement on cone biopsies.