Vascular disease in scleroderma: mechanisms of vascular injury

Vascular endothelial injury in systemic sclerosis (SSc) includes a spectrum of changes that involve predominantly the microcirculation and arterioles. The pathologic changes in the blood vessels adversely impact the physiology of many organ systems, with a reduction in the size of microvascular beds...

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Bibliographic Details
Published inRheumatic diseases clinics of North America Vol. 34; no. 1; p. 57
Main Author Kahaleh, Bashar
Format Journal Article
LanguageEnglish
Published United States 01.02.2008
Subjects
Antibody-Dependent Cell Cytotoxicity - physiology
Autoantibodies - physiology
Endothelium, Vascular - injuries
Endothelium, Vascular - physiopathology
Endothelium-Dependent Relaxing Factors
Humans
Scleroderma, Systemic - complications
Scleroderma, Systemic - physiopathology
Vascular Diseases - etiology
Vascular Diseases - physiopathology
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Summary:Vascular endothelial injury in systemic sclerosis (SSc) includes a spectrum of changes that involve predominantly the microcirculation and arterioles. The pathologic changes in the blood vessels adversely impact the physiology of many organ systems, with a reduction in the size of microvascular beds leading to decreased organ blood flow and ultimately to a state of chronic ischemia. Current hypotheses in SSc vascular disease suggest a possible chemical or infectious trigger.
ISSN:0889-857X
DOI:10.1016/j.rdc.2007.12.004