Eosinophilia in cholesterol atheroembolic disease

Human umbilical vein endothelial cells are an important source of hematopoietic cytokines that promote IL-5-induced eosinophil differentiation from cord blood CD34+ cells.5 Moreover, IL-5 mRNA transcripts have been found in human endothelial cells belonging to different organs,6 whereas only one stu...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 120; no. 6; pp. 1470 - 1471
Main Authors Cecioni, Ilaria, MD, PhD, Fassio, Filippo, MD, Gori, Stefano, MD, Giudizi, Maria Grazia, PhD, Romagnani, Sergio, MD, Almerigogna, Fabio, MD, PhD
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.12.2007
Elsevier Limited
Subjects
Aged
Allergy and Immunology
Cholesterol
Cholesterol - metabolism
Classification
Cytokines
Drug therapy
Embolism, Cholesterol - complications
Eosinophilia - classification
Eosinophilia - diagnosis
Eosinophilia - etiology
Humans
Male
Pathogenesis
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Summary:Human umbilical vein endothelial cells are an important source of hematopoietic cytokines that promote IL-5-induced eosinophil differentiation from cord blood CD34+ cells.5 Moreover, IL-5 mRNA transcripts have been found in human endothelial cells belonging to different organs,6 whereas only one study demonstrated that human bone marrow microvascular endothelial cells secreted low levels of IL-5 after in vitro stimulation.7 On this basis, we believe that atheroembolic disease could represent an interesting example of cytokine-mediated eosinophilic disorder.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2007.07.014