Association of macrophage migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms in acute rheumatic fever

• Published in: Cardiology in the young Vol. 23; no. 4; pp. 486 - 490
• Main Authors: Col-Araz, Nilgun, Pehlivan, Sacide, Baspinar, Osman, Sever, Tugce, Oguzkan-Balci, Sibel, Balat, Ayse
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.08.2013
• Subjects: Adolescent; Autoimmune diseases; Case-Control Studies; Child; Child, Preschool; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Intramolecular Oxidoreductases - genetics; Macrophage Migration-Inhibitory Factors - genetics; Male; Mannose-Binding Lectin - genetics; Original Articles; Polymorphism, Genetic; Rheumatic Fever - genetics; paediatrics; Cytokines; medical genetics
• ISSN: 1047-9511; 1467-1107
• DOI: 10.1017/S1047951112000972

Macrophage migration inhibitory factor and mannose-binding lectin-2 play important roles in the pathogenesis of several acute and chronic inflammatory/autoimmune disorders. The aim of the study was to investigate any possible association between migration inhibitory factor and mannose-binding lectin-2 gene polymorphisms and acute rheumatic fever in children. Material and methods A total of 38 unrelated children with acute rheumatic fever and 40 age- and sex-matched healthy controls were analysed for codon 54 A/B polymorphism in mannose-binding lectin-2 gene and -173 G/C polymorphism in migration inhibitory factor gene by using the polymerase chain reaction method. Frequency of BB genotype of mannose-binding lectin-2 gene was higher in the patient group. Interestingly, children with acute rheumatic fever with AA genotype tended to have chorea compared with children with BB genotype. There was a statistically significant increase in frequency of the migration inhibitory factor -173 CC genotype in patients compared with the control subjects. The present study is the first to investigate the mannose-binding lectin-2 gene polymorphism in children with acute rheumatic fever. BB genotype of mannose-binding lectin-2 (codon 54) and CC genotype of migration inhibitory factor (-173) may have a role in the immunoinflammatory process of acute rheumatic fever.