Intrahepatic Cholestasis of Pregnancy： Biochemical Predictors of Adverse Perinatal Outcomes

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 33; no. 3; pp. 412 - 417
• Main Author: 陈慧 周媛 邓东锐 郝海燕 党静 李静
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.06.2013; Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Obstetrics, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China%Department of Obstetrics and Gynecology, Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
• Subjects: Abortion, Induced; Adult; Bile Acids and Salts - analysis; Biomarkers - metabolism; China; Cholestasis, Intrahepatic - diagnosis; Cholestasis, Intrahepatic - metabolism; Female; Humans; logistic回归分析; Medicine; Medicine & Public Health; Pregnancy; Pregnancy Complications - diagnosis; Pregnancy Complications - metabolism; Prognosis; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Stillbirth; Thiobarbituric Acid Reactive Substances - analysis; Young Adult; 围产期; 妊娠期; 淤积; 生化; 肝; 胆汁酸; 预测; China; cholic acids; pregnancy outcome; intrahepatic cholestasis of pregnancy
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-013-1133-8

Summary： This study aimed to identify biochemical predictors of adverse perinatal outcomes in in- trahepatic cholestasis of pregnancy （ICP）. A total of 106 ICP cases were analyzed retrospectively by the combination of receiver operating characteristic curve and binary logistic regression analysis. ＂Adverse perinatal outcomes＂ included spontaneous preterm labor, meconium-staining of amniotic fluid, stillbirth and Apgar score ≤7 at 1 or 5 min. Total bile acid （TBA） [AUC=0.658, 95%CI （0.536, 0.781）, P=0.031] was a valuable predictor for adverse perinatal outcomes. The critical value of TBA above which adverse perinatal outcomes were observed was 40.15 μmol/L （Youden＇s index=0.3）. Binary multivariate logistic regression analysis revealed that the risk of adverse perinatal outcomes increased when TBA ≥40.15 /.tmol/L [OR=3.792, 95%CI （1.226, 11.727）, P=0.021]. It is concluded that the risk of adverse perinatal outcomes in ICP increases when maternal TBA ≥40.15 gmol/L.