Genetic Basis of XX Male Syndrome and XX True Hermaphroditism: Evidence in the Dog

Serological analysis of white blood cells from the members of a family of American cocker spaniels indicates that a form of abnormal sexual development, in which individuals with a female karyotype have testes or ovotestes, is caused by anomalous transmission of male-determining H-Y genes.

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 201; no. 4356; pp. 644 - 646
Main Authors Selden, Jules R., Wachtel, Stephen S., Koo, Gloria C., Haskins, Mark E., Patterson, Donald F.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 18.08.1978
Subjects
Alcohol drinking
Animal genetics
Animals
Antigens
Antiserum
Cell Differentiation
Disorders of Sex Development - immunology
Disorders of Sex Development - veterinary
Dog Diseases - genetics
Dogs
Female
Genes
Genetic Linkage
Histocompatibility Antigens - genetics
Leukocytes - immunology
Male
Ovary - growth & development
Sex chromosomes
Spermatozoa
Testes
Testis - growth & development
True hermaphroditism
Y chromosome
Y Chromosome - immunology
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Summary:Serological analysis of white blood cells from the members of a family of American cocker spaniels indicates that a form of abnormal sexual development, in which individuals with a female karyotype have testes or ovotestes, is caused by anomalous transmission of male-determining H-Y genes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.675252