Fragilides U-W: New 11,20-Epoxybriaranes from the Sea Whip Gorgonian Coral Junceella fragilis

Three new 11,20-epoxybriaranes-fragilides U-W ( - ), as well as two known metabolites, junceellonoid D ( ) and junceellin ( ), were obtained from the octocoral . The structures of briaranes - were elucidated by spectroscopic methods and briaranes and displayed inhibition effects on inducible nitric...

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Published inMarine drugs Vol. 17; no. 12; p. 706
Main Authors Su, Tung-Pin, Yuan, Chien-Han, Jhu, Yi-Ming, Peng, Bo-Rong, Wen, Zhi-Hong, Wu, Yu-Jen, Wu, Tung-Ying, Liu, Hong-Wen, Sung, Ping-Jyun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 15.12.2019
MDPI
Subjects
Metabolites
Natural products
Nitric oxide
Nitric-oxide synthase
Spectrum analysis
junceellin
fragilide
junceellonoid
Junceella fragilis
iNOS
briarane
gorgonian
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Summary:Three new 11,20-epoxybriaranes-fragilides U-W ( - ), as well as two known metabolites, junceellonoid D ( ) and junceellin ( ), were obtained from the octocoral . The structures of briaranes - were elucidated by spectroscopic methods and briaranes and displayed inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW264.7.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:1660-3397
1660-3397
DOI:10.3390/md17120706