Structural approaches to pathway-specific antimicrobial agents

This perspective provides an overview of the evolution of antibiotic discovery from a largely phenotypic-based effort, through an intensive structure-based design focus, to a more holistic approach today. The current focus on antibiotic development incorporates assay and discovery conditions that re...

Full description

Saved in:
Bibliographic Details
Published inTranslational research : the journal of laboratory and clinical medicine Vol. 220; pp. 114 - 121
Main Authors Johnson, Michael E., Fung, Leslie W.-M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2020
Subjects
MSSA
BARDA
PK
HTS
MIC
MRSA
Online AccessGet full text

Cover

More Information
Summary:This perspective provides an overview of the evolution of antibiotic discovery from a largely phenotypic-based effort, through an intensive structure-based design focus, to a more holistic approach today. The current focus on antibiotic development incorporates assay and discovery conditions that replicate the host environment as much as feasible. They also incorporate several strategies, including target identification and validation within the whole cell environment, a variety of target deconvolution methods, and continued refinement of structure-based design approaches.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2020.02.001