therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer

• Published in: Phytochemistry reviews Vol. 11; no. 4; pp. 567 - 616
• Main Authors: Klein-Júnior, Luiz Carlos, Santin, José Roberto, Niero, Rivaldo, de Andrade, Sérgio Faloni, Cechinel-Filho, Valdir
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer-Verlag 01.12.2012; Springer Netherlands; Springer Nature B.V
• Subjects: adverse effects; alternative medicine; Biochemistry; Biomedical and Life Sciences; chemical structure; Chemistry/Food Science; drugs; Helicobacter pylori; Lead; Life Sciences; mechanism of action; Metabolites; Morbidity; mortality; Natural products; Organic Chemistry; Pathogenesis; peptic ulcers; Plant Genetics and Genomics; Plant Sciences; proton pump; Proton pump inhibitors; Ulcers; Vagotomy; Gastroprotection; Ulcer; Secondary metabolites
• ISSN: 1568-7767; 1572-980X
• DOI: 10.1007/s11101-012-9262-4

For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alternative therapies and the use of natural products. This review emphasizes recent studies involving naturally occurring antiulcer metabolites, categorized according to their chemical structure. Both terrestrial and marine sources are included. More than a hundred and fifty different compounds are presented, and where possible, their main mechanisms of action are summarized. Considering that Helicobacter pylori is an important causal factor in the pathogenesis of ulcer disease, an overview of some natural compounds with anti-H. pylori activity is presented.