Changes in serum iron and leukocyte count associated with open-heart surgery

Rapid and pronounced changes in serum iron concentration and leukocyte count in association with open-heart surgery were observed in each of 58 patients. We examined the temporal aspects of these alterations. An initial increase in Fe concentration from a mean of 0.94 mg/L before surgery to 1.20 mg/...

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Published inClinical chemistry (Baltimore, Md.) Vol. 29; no. 11; pp. 1984 - 1986
Main Authors Fitzsimons, EJ, Ballantyne, GH
Format Journal Article
LanguageEnglish
Published Washington, DC Am Assoc Clin Chem 01.11.1983
American Association for Clinical Chemistry
Subjects
Biological and medical sciences
Cardiac Surgical Procedures
Ferritins - analysis
Humans
Iron - blood
Leukocyte Count
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Time Factors
Heart
Iron
Leukocyte
Cardiotomy
Surgery
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Summary:Rapid and pronounced changes in serum iron concentration and leukocyte count in association with open-heart surgery were observed in each of 58 patients. We examined the temporal aspects of these alterations. An initial increase in Fe concentration from a mean of 0.94 mg/L before surgery to 1.20 mg/L was observed within 6 h of the start of surgery. Decreased Fe concentration, a phenomenon previously associated with physiologically stressful events, became apparent 12 h after surgery, by which time the mean Fe concentration had declined to 0.26 mg/L. An increase in the mean leukocyte count, from 7.1 to 15.2 X 1000/mm3 was observed within 6 h of the start of surgery. An increase in ferritin concentration in serum was concurrent with decreased iron concentration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/29.11.1984