Material extrusion 3D-printing technology: A new strategy for constructing water-soluble, high-dose, sustained-release drug formulations

• Published in: Materials today bio Vol. 27; p. 101153
• Main Authors: Liu, Zhiting, Huang, Jiaying, Fang, Danqiao, Feng, Bohua, Luo, Jianxu, Lei, Peixuan, Chen, Xiaoling, Xie, Qingchun, Chen, Meiwan, Chen, Peihong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2024; Elsevier
• Subjects: Core-shell system; Direct ink writing; Full Length; High drug loading; Material extrusion; Metformin hydrochloride; Sustained release; Material extrusion; Direct ink writing; Sustained release; High drug loading; Metformin hydrochloride; Core-shell system
• ISSN: 2590-0064; 2590-0064
• DOI: 10.1016/j.mtbio.2024.101153

The advantage of low-temperature forming through direct ink writing (DIW) 3D printing is becoming a strategy for the construction of innovative drug delivery systems (DDSs). Optimization of the complex formulation, including factors such as the printing ink, presence of solvents, and potential low mechanical strength, are challenges during process development. This study presents an application of DIW to fabricate water-soluble, high-dose, and sustained-release DDSs. Utilizing poorly compressible metformin hydrochloride as a model drug, a core-shell delivery system was developed, featuring a core composed of 96 % drug powder and 4 % binder, with a shell structure serving as a drug-release barrier. This design aligns with the sustained-release profile of traditional processes, achieving a 25.8 % reduction in volume and enhanced mechanical strength. The strategy facilitates sustained release of high-dose water-soluble formulations for over 12 h, potentially improving patient compliance by reducing formulation size. Process optimization and multi-batch flexibility were also explored in this study. Our findings provide a valuable reference for the development of innovative DDSs and 3D-printed drugs. [Display omitted]