Medulloblastoma: WHO 2021 and Beyond

In 2016, medulloblastoma classification was restructured to allow for incorporation of updated data about medulloblastoma biology, genomics, and clinical behavior. For the first time, medulloblastomas were classified according to molecular characteristics ("genetically defined" categories)...

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Bibliographic Details
Published inPediatric and developmental pathology Vol. 25; no. 1; p. 23
Main Authors Cotter, Jennifer A, Hawkins, Cynthia
Format Journal Article
LanguageEnglish
Published United States 01.01.2022
Subjects
Cerebellar Neoplasms - diagnosis
Cerebellar Neoplasms - genetics
Humans
Medulloblastoma - diagnosis
Medulloblastoma - genetics
World Health Organization
tumors
immunohistochemistry
Surg Path
molecular pathology
neuropathology
oncology
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Summary:In 2016, medulloblastoma classification was restructured to allow for incorporation of updated data about medulloblastoma biology, genomics, and clinical behavior. For the first time, medulloblastomas were classified according to molecular characteristics ("genetically defined" categories) as well as histologic characteristics ("histologically defined" categories). Current genetically-defined categories include WNT-activated, SHH-activated wildtype, SHH-activated -mutant, and non-WNT/non-SHH. In this article, we review the most recent update to the classification of medulloblastomas, provide a practical approach to immunohistochemical and molecular testing for these tumors, and demonstrate how to use key molecular genetic findings to develop an integrated diagnosis.
ISSN:1615-5742
DOI:10.1177/10935266211018931