Anti-nociceptive and anti-inflammatory activity of sophocarpine

• Published in: Journal of ethnopharmacology Vol. 125; no. 2; pp. 324 - 329
• Main Authors: Gao, Yonglin, Li, Guisheng, Li, Chunmei, Zhu, Xiaoyin, Li, Min, Fu, Chaolin, Li, Bafang
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 07.09.2009; Amsterdam; New York: Elsevier; Elsevier
• Subjects: Acetic Acid; alkaloids; Alkaloids - isolation & purification; Alkaloids - pharmacology; Alkaloids - therapeutic use; analgesic effect; Analgesics - chemistry; Analgesics - pharmacology; Analgesics - therapeutic use; animal models; Animals; Anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Anti-nociceptive activity; Biological and medical sciences; Capillary Permeability - drug effects; Carrageenan; Disease Models, Animal; dosage; dose response; Dose-Response Relationship, Drug; Edema - chemically induced; Edema - drug therapy; Female; General pharmacology; inflammation; Inflammation - drug therapy; Male; Medical sciences; medicinal plants; medicinal properties; Mice; Mice, Inbred Strains; pain; Pain - chemically induced; Pain - drug therapy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Rats, Sprague-Dawley; Sophocarpine; Sophora - chemistry; Sophora alopecuroides; Xylenes; Sophocarpine; Anti-inflammatory activity; Anti-nociceptive activity; Analgesic; Pharmacognosy; Antiinflammatory agent; Plant origin; Medicinal plant
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2009.06.036

This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study. Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg). Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.