Anti-nociceptive and anti-inflammatory activity of sophocarpine
This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents. The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above...
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Published in | Journal of ethnopharmacology Vol. 125; no. 2; pp. 324 - 329 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
07.09.2009
Amsterdam; New York: Elsevier Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents.
The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study.
Pretreatment with a single dose of sophocarpine (20 and 40
mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30
mg/kg), xylene-induced mouse ear edema (20 and 40
mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40
mg/kg).
Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes. |
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Bibliography: | http://dx.doi.org/10.1016/j.jep.2009.06.036 |
ISSN: | 0378-8741 1872-7573 |
DOI: | 10.1016/j.jep.2009.06.036 |