Cytoplasmic poly (A) binding protein (PABPC2) critically regulates epidermal maintenance and turnover in planarian Schmidtea mediterranea

• Published in: Development (Cambridge) Vol. 144; no. 17; pp. 3066 - 3079
• Main Authors: Bansal, Dhiru, Kulkarni, Jahnavi, Nadahalli, Kavana, Lakshmanan, Vairavan, Krishna, Srikar, Sasidharan, Vidyanand, Geo, Jini, Dilipkumar, Shilpa, Pasricha, Renu, Gulyani, Akash, Raghavan, Srikala, Palakodeti, Dasaradhi
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.09.2017
• Subjects: Animals; Cell Lineage; Cell Proliferation; Cytoplasm - metabolism; Epidermis; Epidermis - metabolism; Epithelium - metabolism; Extracellular matrix; Extracellular Matrix - metabolism; Gene Knockdown Techniques; Homeostasis; Models, Biological; Planarians - genetics; Planarians - metabolism; Poly(A)-Binding Protein I - metabolism; Regeneration; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stem cells; Stem Cells and Regeneration; Wound Healing; Poly (A)-binding proteins; Regeneration; Epidermis; Neoblast; Planaria

Identifying key cellular events that facilitate stem cell function and tissue organization is critical for understanding the process of regeneration. Planarians are powerful model system to study regeneration and stem cell (neoblast) function. Here, using planaria, we show that the initial events of...