Vitamin K deficiency syndromes in warfarin-resistant brown rats (Rattus norvegicus)

Resistance to the anticoagulant rodenticide warfarin and an increased vitamin K requirement appear to be pleiotropic effects of the gene Rw 2. A comparison of pup mortality in F2 (Rw 1 Rw 2 × Rw 1 Rw 2) and backcross (Rw 1 Rw 2 × Rw 1 Rw 1 or reciprocal) matings of wild brown rats in the laboratory...

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Bibliographic Details
Published inLaboratory animals (London) Vol. 14; no. 3; pp. 193 - 195
Main Author Partridge, G.G
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.1980
Subjects
Alleles
Animals
Animals, Newborn - genetics
Drug Resistance
Female
Male
Mortality
Pregnancy
Rats - genetics
Rattus norvegicus
Rodent Diseases - genetics
Vitamin K Deficiency - genetics
Vitamin K Deficiency - veterinary
Warfarin
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Summary:Resistance to the anticoagulant rodenticide warfarin and an increased vitamin K requirement appear to be pleiotropic effects of the gene Rw 2. A comparison of pup mortality in F2 (Rw 1 Rw 2 × Rw 1 Rw 2) and backcross (Rw 1 Rw 2 × Rw 1 Rw 1 or reciprocal) matings of wild brown rats in the laboratory revealed significantly greater losses in the F2 litters at 4-8 weeks of age. Some deaths could be attributed directly to haemorrhage resulting from vitamin K deficiency. A newborn warfarin-resistant rat from an F2 litter showed bleeding from the umbilicus and the anus, and died from internal haemorrhage at 18 weeks of age. Another warfarin-resistant male rat dying at the same age had a grossly enlarged skull.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0023-6772
1758-1117
DOI:10.1258/002367780780937616