Circulating microRNAs

The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress in the field including the ability of miRNAs to participate in intercellular communication i...

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Bibliographic Details
Published inBiochemistry (Moscow) Vol. 80; no. 9; pp. 1117 - 1126
Main Authors Makarova, J. A., Shkurnikov, M. U., Turchinovich, A. A., Tonevitsky, A. G., Grigoriev, A. I.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2015
Springer
Springer Nature B.V
Subjects
Animals
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Body fluids
Cancer
Cell Communication
Humans
Life Sciences
Methods
Microbiology
MicroRNA
MicroRNAs
MicroRNAs - blood
MicroRNAs - metabolism
Molecular biology
Pathology, Molecular
Physiological aspects
Plasma
Review
RNA sequencing
RNA, Small Untranslated - blood
RNA, Small Untranslated - secretion
miRNA
cancer
noncoding RNA
exosomes
biomarkers
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Summary:The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress in the field including the ability of miRNAs to participate in intercellular communication in vitro and in vivo , and the application of circulating miRNAs as diagnostic markers of a wide range of diseases. Special attention is paid to the relevance of the development and unification of current techniques for isolation of circulating miRNAs.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297915090035