Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower

• Published in: Journal of ethnopharmacology Vol. 130; no. 1; pp. 179 - 182
• Main Authors: William Carey, M., Rao, N. Venkat, Kumar, B. Ravi, Mohan, G. Krishna
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 06.07.2010; Amsterdam; New York: Elsevier; Elsevier
• Subjects: Analgesic activity; analgesic effect; Analgesics - pharmacology; animal models; Animals; Anti-inflammatory; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Ayurvedic medicine; Bignoniaceae - chemistry; Biological and medical sciences; dosage; dose response; Dose-Response Relationship, Drug; flowers; General pharmacology; inflammation; Kigelia; Kigelia pinnata; Kigelia pinnata DC flower; Medical sciences; medicinal plants; medicinal properties; methanol; Methanol - chemistry; Mice; pain; Paw licking; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; Plant Extracts - pharmacology; Rats; India; Kigelia pinnata DC flower; Anti-inflammatory; Analgesic activity; Paw licking; Flower; Pharmacognosy; Antiinflammatory agent; Extract; Medicinal plant; Analgesic; Dicotyledones; Angiospermae; Plant origin; Spermatophyta; Bignoniaceae
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2010.04.023

The methanolic extract of Kigelia pinnata DC flower exhibited anti-inflammatory and analgesic activities. The present study confirms the claimed utilization of the plant against pain and inflammatory complaints in Indian folklore medicine. Kigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders. The aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners. MKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice. MKFL exhibited a significant ( P < 0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400 mg/kg b.w. in rats and mice respectively. The results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders.