Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis

• Published in: Journal of functional foods Vol. 17; pp. 575 - 586
• Main Authors: Cazarin, Cinthia Baú Betim, da Silva, Juliana Kelly, Colomeu, Talita Cristina, Batista, Ângela Giovana, Meletti, Laura Maria Molina, Paschoal, Jonas Augusto Rizzato, Bogusz Junior, Stanislau, Braga, Patrícia Aparecida de Campos, Reyes, Felix Guillermo Reyes, Augusto, Fábio, de Meirelles, Luciana Rodrigues, Zollner, Ricardo de Lima, Maróstica Júnior, Mário Roberto
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.08.2015; Elsevier
• Subjects: Anti-inflammatory activity; Antioxidant potential; Colitis; Oxidative stress; Passiflora edulis leaves; Oxidative stress; Anti-inflammatory activity; Colitis; Passiflora edulis leaves; Antioxidant potential
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2015.05.034

•Intake of Passiflora edulis leaves aqueous intake source of antioxidants.•P. edulis leaf aqueous extract inhibits cytokines in serum and colon tissue.•P. edulis leaf extract improves the antioxidant status and decreases lipid peroxidation. The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 µg mL−1) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1β five-fold and TNF-α two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease.