Cyclocarya paliurus leaves alleviate hyperuricemic nephropathy via modulation of purine metabolism, antiinflammation, and antifibrosis

• Published in: Journal of functional foods Vol. 103; p. 105485
• Main Authors: Gui, Rui, Wang, Yi-Kun, Wu, Jian-Ping, Deng, Gui-Ming, Cheng, Fei, Zeng, Hong-Liang, Zeng, Pu-Hua, Long, Hong-Ping, Zhang, Wei, Wei, Xi-Fan, Wang, Wen-Xuan, Zhu, Gang-Zhi, Ren, Wei-Qiong, Chen, Zu-Hui, He, Xiao-Ai, Xu, Kang-Ping
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.04.2023; Elsevier
• Subjects: Antifibrosis; Antiinflammation; Cyclocarya paliurus; Hyperuricemic nephropathy; Modulation of purine metabolism; Modulation of purine metabolism; Hyperuricemic nephropathy; Antiinflammation; Cyclocarya paliurus; Antifibrosis
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2023.105485

[Display omitted] •The water extracts of Cyclocarya paliurus leaves could reduce uric acid by improving purine metabolism in hyperuricemic nephropathy rats.•The water extracts of C. paliurus leaves could ameliorate kidney inflammation through improving arachidonic acid metabolism and reducing kidney cytokine.•The water extracts of C. paliurus leaves had a significant renoprotective effect by attenuating kidney fibrosis in hyperuricemic nephropathy rats. Cyclocarya paliurus, as an important edible and medicinal plant, its effects and mechanisms on hyperuricemic nephropathy remain unclear. Herein, we investigated the hypouricemic and nephroprotective effects of the water extracts of C. paliurus leaves (CPE) in a hyperuricemic nephropathy rat model induced by adenine and ethambutol. The results showed that CPE could significantly decrease plasma uric acid (PUA) and urea nitrogen (PUN), as well as reduce renal fibrosis in the hyperuricemic nephropathy rat model. Plasma metabolomics indicated that CPE improved the disordered arachidonic acid metabolism. Meanwhile, CPE reduced renal inflammation via inhibition of COX--2. Moreover, CPE could improve disturbed purine metabolism by inhibiting the hepatic xanthine oxidase (XOD), reversing the renal urate transporter 1 (URAT1) and organic anion transporter 1 (OAT1). Collectively, this study demonstrated that CPE could exhibit hypouricemic effect by improving purine metabolism, and attenuate kidney injury by improving arachidonic acid metabolism and alleviating kidney inflammation.