Serum Bisphenol A Concentrations Showed Gender Differences, Possibly Linked to Androgen Levels

To investigate human exposure to bisphenol A (BPA), a widely used endocrine disruptor, we measured serum BPA concentrations and analyzed the interrelation of BPA with sex-related hormones. BPA was detected in all human sera by a novel enzyme-linked immunosorbent assay. Serum BPA concentrations were...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 291; no. 1; pp. 76 - 78
Main Authors Takeuchi, Toru, Tsutsumi, Osamu
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.02.2002
Subjects
Adult
Androgens - blood
Androstenedione - blood
Benzhydryl Compounds
bisphenol A
Body Mass Index
Dehydroepiandrosterone Sulfate - blood
endocrine disruptor
Enzyme-Linked Immunosorbent Assay
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
gender difference
human
Humans
Luteinizing Hormone - blood
Male
Phenols - blood
polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Prolactin - blood
Sex Factors
testosterone
Testosterone - blood
endocrine disruptor
bisphenol A
gender difference
testosterone
human
polycystic ovary syndrome
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Summary:To investigate human exposure to bisphenol A (BPA), a widely used endocrine disruptor, we measured serum BPA concentrations and analyzed the interrelation of BPA with sex-related hormones. BPA was detected in all human sera by a novel enzyme-linked immunosorbent assay. Serum BPA concentrations were significantly higher in normal men (1.49 ± 0.11 ng/ml; P < 0.01) and in women with polycystic ovary syndrome (1.04 ± 0.10 ng/ml; P < 0.05) compared with normal women (0.64 ± 0.10 ng/ml). There were significant positive correlations between serum BPA and total testosterone (r = 0.595, P < 0.001) and free testosterone (r = 0.609, P < 0.001) concentrations in all subjects and likewise between serum BPA and total testosterone (r = 0.559, P < 0.01) and free testosterone (r = 0.598, P < 0.001) concentrations in all female subjects, but not between serum BPA and other sex-related hormone concentrations in any group. These findings showed that there are gender differences in serum BPA concentrations, possibly due to differences in the androgen-related metabolism of BPA.
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ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2002.6407