The Impact of Primary Tumor and Locoregional Metastatic Lymph Node SUVmax on Predicting Survival in Patients with Rectal Cancer

• Published in: Molecular imaging and radionuclide therapy Vol. 29; no. 2; pp. 65 - 71
• Main Authors: Alçın, Göksel, Şanlı, Yasemin, Yeğen, Gülçin, Kaytan Sağlam, Esra, Çermik, Tevfik Fikret
• Format: Journal Article
• Language: English
• Published: Ankara Türkiye Nükleer Tıp Derneği 01.06.2020; Galenos Publishing House; Galenos Publishing
• Subjects: Adenocarcinoma; Biopsy; Colorectal cancer; Computed tomography; Fluorine isotopes; Localization; Lymph nodes; Lymphatic system; Medical imaging; Medical prognosis; Metastases; Metastasis; Mortality; Mutation; Original; Pathology; Patients; Positron emission; Positron emission tomography; Rectum; Software; Statistical analysis; Survival; Tıp; Tomography; Tumors; Ankara; Türkiye; 18F-FDG PET/BT; SUVmaks; prognoz; 18F-FDG PET/CT; Rectal adenocarcinoma; evreleme; SUVmax; staging; prognosis; Rektum kanseri
• ISSN: 2146-1414; 2147-1959
• DOI: 10.4274/mirt.galenos.2020.40316

Objectives: The aim of this study was to evaluate the impact of maximum standard uptake value (SUVmax) of the primary tumor and locoregional metastatic lymph node in predicting survival in patients with the preoperative rectal adenocarcinoma. Methods: One hundred and fifteen patients [mean age ± standard deviation (SD): 58.7±11.4 years] with biopsy-proven rectal adenocarcinoma underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging for the staging were included in this study. All patients were followed-up for a minimum of 12 months (mean ± SD: 29.7±13.5 months). Tumor-node-metastasis 2017 clinical staging, SUVmax of the primary rectal tumor and locoregional lymph nodes on the PET/CT studies were evaluated. Results: All patients had increased FDG activity of the primary tumor. The mean ± SD SUVmax of the primary tumor and locoregional metastatic lymph node were 21.0±9.1 and 4.6±2.8, respectively. Primary tumor SUVmax did not have an effect on predicting survival (p=0.525) however locoregional metastatic lymph node SUVmax had an effect (p<0.05) on predicting survival. Clinical stage of the disease was a factor predicting survival (p<0.001). Conclusion: 18F-FDG PET/CT is an effective imaging modality for detecting primary tumors and metastases in rectal adenocarcinoma and clinical stage assessment with PET/CT had an effect on predicting survival. Furthermore, in our study locoregional lymph node SUVmax was defined as a factor in predicting survival.