Latent pulmonary function abnormalities in children with Crohn's disease

• Published in: The European respiratory journal Vol. 8; no. 3; pp. 377 - 380
• Main Authors: Munck, A, Murciano, D, Pariente, R, Cezard, JP, Navarro, J
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.03.1995; Maney
• Subjects: Adolescent; Biological and medical sciences; Child; Crohn Disease - complications; Crohn Disease - physiopathology; Female; Humans; Lung - physiopathology; Male; Medical sciences; Pneumology; Pulmonary Gas Exchange - physiology; Respiratory Function Tests; Respiratory system : syndromes and miscellaneous diseases; Human; Crohn disease; Lung disease; Lung function; Respiratory disease; Digestive diseases; Intestinal disease; Complication; Exploration; Child; Inflammatory disease
• ISSN: 0903-1936; 1399-3003
• DOI: 10.1183/09031936.95.08030377

Recently, latent pulmonary involvement has been described in adult patients with inflammatory bowel disease. It is unknown, however, whether this also occurs in children, and whether the pulmonary abnormalities differ between the acute phase and remission. The incidence of pulmonary abnormalities has been investigated in 26 children with acute or quiescent Crohn's disease in terms of the following parameters: clinical pulmonary symptoms, chest roentgenograms and pulmonary function tests, including lung transfer factor for carbon monoxide (TLCO). One child had a severe digital clubbing. Chest radiographs were normal in all subjects. No significant differences were found between acute and quiescent phase for pulmonary volumes and expiratory flows, but TLCO (% predicted) was significantly decreased during the active phase of the disease as compared to remission (53 +/- 15 vs 81 +/- 19% predicted). These data suggest that latent pulmonary involvement is also present in a paediatric population with active Crohn's disease, despite a short disease history and absence of smoking. Although the nature of this abnormality remains unclear, this extradigestive epiphenomenon should be taken into account with respect to the aetiopathogenesis of Crohn's disease.