Novel insights into ferroptosis: Implications for age-related diseases

Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eve...

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Published inTheranostics Vol. 10; no. 26; pp. 11976 - 11997
Main Authors Zhou, Ren-Peng, Chen, Yong, Wei, Xin, Yu, Bin, Xiong, Zhi-Gang, Lu, Chao, Hu, Wei
Format Journal Article Book Review
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2020
Ivyspring International Publisher
Subjects
Alzheimer's disease
Antioxidants
Apoptosis
Biomarkers
Biosynthesis
Ferroptosis
Homeostasis
Lipid peroxidation
Lipids
Metabolism
Mitochondria
Morphology
Pathogenesis
Proteins
Regulation
Review
age-related diseases
iron
ferroptosis
lipid peroxidation
reactive oxygen species
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Summary:Rapid increase in aging populations is an urgent problem because older adults are more likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare systems and society in general. ARDs are characterized by the progressive deterioration of tissues and organs over time, eventually leading to tissue and organ failure. To date, there are no effective interventions to prevent the progression of ARDs. Hence, there is an urgent need for new treatment strategies. Ferroptosis, an iron-dependent cell death, is linked to normal development and homeostasis. Accumulating evidence, however, has highlighted crucial roles for ferroptosis in ARDs, including neurodegenerative and cardiovascular diseases. In this review, we a) summarize initiation, regulatory mechanisms, and molecular signaling pathways involved in ferroptosis, b) discuss the direct and indirect involvement of the activation and/or inhibition of ferroptosis in the pathogenesis of some important diseases, and c) highlight therapeutic targets relevant for ARDs.
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These authors contributed equally to this work and should be considered co-first authors.
Competing Interests: The authors have declared that no competing interest exists.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.50663