Bioactive Secondary Metabolites from the Culture of the Mangrove-Derived Fungus Daldinia eschscholtzii HJ004

Two new polyketides, 8- -methylnodulisporin F ( ) and nodulisporin H ( ), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone ( ) and 5-hydroxy-2-methoxynaphtho[9- ]furan-1,4-dione ( ), and a new naphthofuran 1,3,8-trimethoxynaphtho[9- ]furan ( ), along with five known compo...

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Published inMarine drugs Vol. 17; no. 12; p. 710
Main Authors Liao, Hai-Xia, Shao, Tai-Ming, Mei, Rong-Qing, Huang, Guo-Lei, Zhou, Xue-Ming, Zheng, Cai-Juan, Wang, Chang-Yun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.12.2019
MDPI
Subjects
Antibacterial activity
Antibiotics
Carbohydrates
Carbon
Circular dichroism
Daldinia eschscholtzii
Diabetes
Dichroism
Drug resistance
Fungi
Glucosidase
Mangroves
Metabolites
Methicillin
Minimum inhibitory concentration
NMR
Nuclear magnetic resonance
Orthosporin
Polyketides
Secondary metabolites
Staphylococcus aureus
α-Glucosidase
antibacterial activity
naphthoquinones
α-glucosidase inhibitory activity
polyketides
Daldinia eschscholtzii
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Summary:Two new polyketides, 8- -methylnodulisporin F ( ) and nodulisporin H ( ), two new naphthoquinones, 5-hydroxy-2-methoxy-6,7-dimethyl-1,4-naphthoquinone ( ) and 5-hydroxy-2-methoxynaphtho[9- ]furan-1,4-dione ( ), and a new naphthofuran 1,3,8-trimethoxynaphtho[9- ]furan ( ), along with five known compounds 4- -methyl eleutherol ( ), 2-acetyl-7-methoxybenzofuran ( ), (-)-orthosporin ( ), diaporthin ( ), and 6-hydroxymellein ( ), were obtained from the EtOAc extract of the mangrove-derived fungus HJ004. The structures of the isolated compounds were elucidated by extensive NMR and MS analyses, while the absolute configurations of the stereogenic carbons were established based on experimental and calculated electronic circular dichroism spectra. Compounds and displayed a potent inhibitory activity against -glucosidase with the IC values of 5.7 and 1.1 μg/mL, respectively. Compounds and showed a moderate antibacterial activity against , methicillin-resistant (MRSA) and , with minimum inhibitory concentration (MIC) values ranging from 6.25 to 12.5 μg/mL. Compound exhibited antibacterial activity against with the MIC value of 12.5 μg/mL.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md17120710