Loss of FrmB results in increased size of developmental structures during the multicellular development of Dictyostelium cells
FERM domain-containing proteins are involved in diverse biological and pathological processes, including cell-substrate adhesion, cell-cell adhesion, multicellular development, and cancer metastasis. In this study, we determined the functions of FrmB, a FERM domain-containing protein, in the cell mo...
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Published in | The journal of microbiology Vol. 55; no. 9; pp. 730 - 736 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Seoul
The Microbiological Society of Korea
01.09.2017
Springer Nature B.V 한국미생물학회 |
Subjects | |
Online Access | Get full text |
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Summary: | FERM domain-containing proteins are involved in diverse biological and pathological processes, including cell-substrate adhesion, cell-cell adhesion, multicellular development, and cancer metastasis. In this study, we determined the functions of FrmB, a FERM domain-containing protein, in the cell morphology, cell adhesion, and multicellular development of
Dictyostelium
cells. Our results show that FrmB appears to play an important role in regulating the size of developmental structures.
frmB
null cells showed prolonged aggregation during development, resulting in increased size of developmental structures, such as mounds and fruiting bodies, compared to those of wild-type cells, whereas FrmB overexpressing cells exhibited decreased size of developmental structures. These results suggest that FrmB may be necessary for limiting the sizes of developmental structures. Loss of FrmB also resulted in decreased cell-substrate adhesion and slightly increased cell area, suggesting that FrmB had important roles in the regulation of cell adhesion and cell morphology. These studies would contribute to our understanding of the intertwined and overlapped functions of FERM domain-containing proteins. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1225-8873 1976-3794 |
DOI: | 10.1007/s12275-017-7221-x |