Anti-inflammatory and anti-pyretic activities of earthworm extract— Lampito mauritii (Kinberg)
Experiments were conducted to understand the therapeutic properties such as anti-inflammatory and anti-pyretic activities of biologically active extract isolated from whole earthworm ( Lampito mauritii, Kinberg). Inflammation in the hind paw of Wistar albino rat, Rattus norvegicus, was induced by hi...
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Published in | Journal of ethnopharmacology Vol. 121; no. 2; pp. 330 - 332 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
21.01.2009
Amsterdam; New York: Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Experiments were conducted to understand the therapeutic properties such as anti-inflammatory and anti-pyretic activities of biologically active extract isolated from whole earthworm (
Lampito mauritii, Kinberg).
Inflammation in the hind paw of Wistar albino rat,
Rattus norvegicus, was induced by histamine, granuloma pouch was induced by turpentine and pyrexia induced by Brewer's yeast in rats were followed as earlier studies. Anti-inflammatory drug—indomethacin and anti-pyretic drug—paracetamol were used as standard drug for comparison.
Administration of indomethacin (10
mg/kg), paracetamol (150
mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200
mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats.
The most significant inhibition of paw oedema and granuloma and also the significant reduction in hyperpyrexia in rats when treated with standard drugs as well as different doses of EE, reflect the presence of anti-inflammatory and anti-pyretic properties of EE similar to glycoprotein complex (G-90). |
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Bibliography: | http://dx.doi.org/10.1016/j.jep.2008.10.021 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0378-8741 1872-7573 |
DOI: | 10.1016/j.jep.2008.10.021 |