Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -...

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Published inRSC advances Vol. 13; no. 46; pp. 32786 - 32823
Main Authors Alshammari, Mohammed B, Aly, Ashraf A, Ahmad, Akil, Brown, Alan B, Mohamed, Asmaa H
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 07.11.2023
The Royal Society of Chemistry
Subjects
Biological activity
Chemistry
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Summary:Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. Spiro heterocycles such as spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives have been found to exhibit diversified biological and pharmacological activity in addition to their therapeutic properties. In view of these facts, we decided in this review to present representative synthetic approaches of the aforementioned spiro heterocycles, especially in the past 20 years. Spiro-heterocycles have received special attention in medicinal chemistry because of their promising biological activity.
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ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra06054c