Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities

Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichrois...

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Published inRSC advances Vol. 9; no. 14; pp. 7961 - 7966
Main Authors Wu, Zhong-Nan, Niu, Qian-Wen, Zhang, Yu-Bo, Luo, Ding, Li, Qing-Guo, Li, Ying-Ying, Kuang, Guang-Kai, He, Li-Jun, Wang, Guo-Cai, Li, Yao-Lan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2019
The Royal Society of Chemistry
Subjects
Biotechnology
Chemistry
Crystallography
Cytotoxicity
Dichroism
Infrared analysis
NMR
Nuclear magnetic resonance
Spectrum analysis
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Summary:Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichroism (ECD) spectroscopy and Rh (OCOCF ) -induced ECD. All compounds were tested for their cytotoxic activities on human HepG-2, HeLa, MCF-7, and A549 cell lines 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 5 exhibited significant cytotoxicities against HepG-2, HeLa and A549 cell lines with IC values of 9.52 ± 0.27, 11.87 ± 0.22 and 12.63 ± 0.12 μM, respectively.
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ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra00277d