The Mouse ZFH-4 Protein Contains Four Homeodomains and Twenty-Two Zinc Fingers
We isolated the mouse zfh-4 cDNA which is 12 kb long and capable of encoding a 3,550-amino acid protein containing four homeodomains and 22 zinc fingers including two pseudo zinc finger motifs. The mouse ZFH-4 is 51% homologous to the mouse ATBF1 and 23% to the Drosophila ZFH-2. The homeodomain and...
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| Published in | Biochemical and biophysical research communications Vol. 273; no. 2; pp. 686 - 693 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
05.07.2000
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| Abstract | We isolated the mouse zfh-4 cDNA which is 12 kb long and capable of encoding a 3,550-amino acid protein containing four homeodomains and 22 zinc fingers including two pseudo zinc finger motifs. The mouse ZFH-4 is 51% homologous to the mouse ATBF1 and 23% to the Drosophila ZFH-2. The homeodomain and zinc finger regions are highly conserved between ZFH-4 and ATBF1 except that one zinc finger is missing in ZFH-4. Analysis of partial genomic sequences showed that the mouse zfh-4 and ATBF1 genes are similar in exon-intron organization. RT-PCR analysis of zfh-4 transcripts in adult mouse tissues showed that zfh-4 expression was low but reproducibly detectable in brain, heart, lung and muscle. In these mouse tissues, ATBF1 transcripts were poorly amplified by PCR under the conditions where zfh-4 transcripts were amplified, suggesting that the expression of zfh-4 mRNA is higher than that of ATBF1 mRNA. Other comparative analysis suggests functional similarities and dissimilarities between ZFH-4 and ATBF1. |
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| AbstractList | We isolated the mouse zfh-4 cDNA which is 12 kb long and capable of encoding a 3,550-amino acid protein containing four homeodomains and 22 zinc fingers including two pseudo zinc finger motifs. The mouse ZFH-4 is 51% homologous to the mouse ATBF1 and 23% to the Drosophila ZFH-2. The homeodomain and zinc finger regions are highly conserved between ZFH-4 and ATBF1 except that one zinc finger is missing in ZFH-4. Analysis of partial genomic sequences showed that the mouse zfh-4 and ATBF1 genes are similar in exon-intron organization. RT-PCR analysis of zfh-4 transcripts in adult mouse tissues showed that zfh-4 expression was low but reproducibly detectable in brain, heart, lung and muscle. In these mouse tissues, ATBF1 transcripts were poorly amplified by PCR under the conditions where zfh-4 transcripts were amplified, suggesting that the expression of zfh-4 mRNA is higher than that of ATBF1 mRNA. Other comparative analysis suggests functional similarities and dissimilarities between ZFH-4 and ATBF1. |
| Author | Sakata, Nobuo Ma, Dongping Miura, Yutaka Kato, Taiji Tamaoki, Taiki Kawaguchi, Makoto Noguchi, Shigeru Hori, Makoto Sasahara, Masakiyo Hemmi, Kazunori |
| Author_xml | – sequence: 1 givenname: Nobuo surname: Sakata fullname: Sakata, Nobuo organization: Department of Biochemistry, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan – sequence: 2 givenname: Kazunori surname: Hemmi fullname: Hemmi, Kazunori organization: Department of Biochemistry, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan – sequence: 3 givenname: Makoto surname: Kawaguchi fullname: Kawaguchi, Makoto organization: Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan – sequence: 4 givenname: Yutaka surname: Miura fullname: Miura, Yutaka organization: Department of Bioregulation Research, Nagoya City University Medical School, Nagoya, Aichi, 467-8601, Japan – sequence: 5 givenname: Shigeru surname: Noguchi fullname: Noguchi, Shigeru organization: Meiji Institute of Health Science, Odawara, Kanagawa, 250-0862, Japan – sequence: 6 givenname: Dongping surname: Ma fullname: Ma, Dongping organization: Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N.W. Calgary, Alberta, T2N 4N1, Canada – sequence: 7 givenname: Masakiyo surname: Sasahara fullname: Sasahara, Masakiyo organization: Department of Pathology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan – sequence: 8 givenname: Taiji surname: Kato fullname: Kato, Taiji organization: Department of Bioregulation Research, Nagoya City University Medical School, Nagoya, Aichi, 467-8601, Japan – sequence: 9 givenname: Makoto surname: Hori fullname: Hori, Makoto organization: Department of Biochemistry, Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan – sequence: 10 givenname: Taiki surname: Tamaoki fullname: Tamaoki, Taiki organization: Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive N.W. Calgary, Alberta, T2N 4N1, Canada |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10873665$$D View this record in MEDLINE/PubMed |
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| Keywords | transcription factor ATBF1 ZFH-2 zinc finger homeodomain ZFH-4 |
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| Snippet | We isolated the mouse zfh-4 cDNA which is 12 kb long and capable of encoding a 3,550-amino acid protein containing four homeodomains and 22 zinc fingers... |
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| SubjectTerms | Amino Acid Motifs - genetics Amino Acid Sequence Animals ATBF1 Base Sequence Cloning, Molecular DNA Primers - genetics DNA, Complementary - genetics DNA, Complementary - isolation & purification Exons Gene Expression homeodomain Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Introns Mice Molecular Sequence Data Restriction Mapping Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Amino Acid transcription factor ZFH-2 ZFH-4 zinc finger Zinc Fingers - genetics |
| Title | The Mouse ZFH-4 Protein Contains Four Homeodomains and Twenty-Two Zinc Fingers |
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