“Smart” alginate hydrogels in biosensing, bioactuation and biocomputing: State-of-the-art and perspectives

•The paper overviews the alginate hydrogels, particularly used.•as matrices for “smart” biomedical devices.•as biosensors.•as bioactuators.•as biocomputing systems.•The paper offers.•state-of-the-art in biomedicine.•perspectives, insights and conclusions. In addressing the demand for biocompatible w...

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Bibliographic Details
Published inSensors and actuators reports Vol. 4; p. 100095
Main Authors Roquero, Daniel Massana, Katz, Evgeny
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.11.2022
Elsevier
Subjects
Biocomputation
Biosensors
Drug delivery
Hydrogels
Smart alginate
Drug delivery
Hydrogels
Biosensors
Biocomputation
Smart alginate
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Summary:•The paper overviews the alginate hydrogels, particularly used.•as matrices for “smart” biomedical devices.•as biosensors.•as bioactuators.•as biocomputing systems.•The paper offers.•state-of-the-art in biomedicine.•perspectives, insights and conclusions. In addressing the demand for biocompatible wearable, implantable and injectable biomedical devices, alginate hydrogels stand out as promising candidates. Alginate hydrogels have been used as matrix for immobilization of proteins, responsive polymers and nanomaterials that lead to a wide range of stimuli-responsive “smart” (bio)(nano)composite hydrogels. In this perspective, we analyzed the most recent applications of “smart” alginate composite hydrogels in biomedical applications, such as biosensing, drug delivery, wound healing and biocomputing. The design and key-responsive element of the composites were discussed as well as their practical application in biologically relevant conditions and in vivo. Finally, we provide our insights into the limitations, challenges and future directions of this exciting research field. [Display omitted]
ISSN:2666-0539
2666-0539
DOI:10.1016/j.snr.2022.100095