Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis

Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that...

Full description

Saved in:
Bibliographic Details
Published inBioMed research international Vol. 2016; no. 2016; pp. 1 - 8
Main Authors Luo, Wei, Lei, Guanghua, Gao, Shuguang, Li, Liangjun, Tu, Min, Zeng, Chao, Deng, Zhenhan, Wang, Hua, Jiang, Wei, Li, Yusheng, Xiao, Wenfeng
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
Online AccessGet full text

Cover

Abstract Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- κ B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF- κ B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF- κ B pathway.
AbstractList Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- κ B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF- κ B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF- κ B pathway.
Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF-κB pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF-κB pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF-κB pathway.
Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- Kappa B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF- Kappa B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF- Kappa B pathway.
Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- κ B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF- κ B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF- κ B pathway.
Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF- B pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF- B pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF- B pathway.
Author Xiao, Wenfeng
Tu, Min
Li, Liangjun
Gao, Shuguang
Jiang, Wei
Zeng, Chao
Li, Yusheng
Luo, Wei
Deng, Zhenhan
Lei, Guanghua
Wang, Hua
AuthorAffiliation 2 Department of Bone and Joint, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen 518020, China
1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410078, China
3 Department of Orthopaedics, Second People's Hospital of Jingmen, Jingmen 448000, China
4 Department of Joint Surgery, Changsha Central Hospital, Changsha 410000, China
AuthorAffiliation_xml – name: 4 Department of Joint Surgery, Changsha Central Hospital, Changsha 410000, China
– name: 3 Department of Orthopaedics, Second People's Hospital of Jingmen, Jingmen 448000, China
– name: 2 Department of Bone and Joint, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen 518020, China
– name: 1 Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410078, China
Author_xml – sequence: 1
  fullname: Luo, Wei
– sequence: 2
  fullname: Lei, Guanghua
– sequence: 3
  fullname: Gao, Shuguang
– sequence: 4
  fullname: Li, Liangjun
– sequence: 5
  fullname: Tu, Min
– sequence: 6
  fullname: Zeng, Chao
– sequence: 7
  fullname: Deng, Zhenhan
– sequence: 8
  fullname: Wang, Hua
– sequence: 9
  fullname: Jiang, Wei
– sequence: 10
  fullname: Li, Yusheng
– sequence: 11
  fullname: Xiao, Wenfeng
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27656654$$D View this record in MEDLINE/PubMed
BookMark eNqNkV1PFDEUhhuCAUTuuDa9JNGRnn7NzA0JEFATEBPluunOnN2tmW2Htqv41_wR_ia77rrBO3pz2vTJk_PmfUl2ffBIyDGwdwBKnXIG-lQLqbTSO-SAC5CVBgm727sQ--QopW-snAY0a_Ue2ed14bWSB8TdpYxhDD47Tz_HsAgZE716HCOm5IKnYUpvbY7ukd5itsMQxlgQ521CCoLmeQzL2Zx-uq5-_7qgX9zM28H5GS26v2obC-KyS6_Ii6kdEh5t5iG5v776evmhurl7__Hy_KbqJNO5sozhpKxeJm-U7surw1qXUBNhoZcSddOJtm9L_prVaEF0om-b1vKuqTmIQ3K29o7LyQL7Dn2OdjBjdAsbf5pgnfn_x7u5mYXvRjEOUusiONkIYnhYYspm4VKHw2A9hmUy0Ki2Bi2FegbK6xYUVyvr2zXaxZBSxOl2I2Bm1aVZdWk2XRb89dMUW_hfcwV4swbmzvf2h3umDguDU_uEbhspmfgDA6Czkg
CitedBy_id crossref_primary_10_12677_ACM_2022_127953
crossref_primary_10_1007_s10735_022_10067_9
crossref_primary_10_1139_bcb_2021_0004
crossref_primary_10_3389_fcimb_2022_705647
crossref_primary_10_18632_aging_203707
crossref_primary_10_1155_2020_3428587
Cites_doi 10.1186/ar326
10.1016/j.joca.2009.07.009
10.1007/s00296-012-2548-4
10.1016/j.jep.2015.07.039
10.1177/1721727X1301100201
10.3892/etm.2014.1750
10.3892/etm.2015.2310
10.1007/s00296-014-3036-9
10.1111/j.1749-6632.1995.tb44633.x
10.1016/j.clim.2014.11.008
10.1016/j.intimp.2014.10.029
10.1002/art.24705
10.1371/journal.pone.0088335
10.3892/etm.2015.2433
10.2741/a463
10.1016/j.clinbiochem.2009.02.002
10.1016/j.joca.2012.09.006
10.1186/1471-2474-13-168
10.1002/1529-0131(200103)44:3<585::AID-ANR107>3.0.CO;2-C
10.1111/iej.12043
10.1186/ar380
10.1016/s0167-5699(00)01715-1
10.1155/2013/596716
10.1007/s00223-002-1025-6
10.4049/jimmunol.147.9.2902
10.1007/s00296-011-2339-3
10.1002/jcb.23298
10.3892/etm.2015.2434
10.1016/j.micpath.2015.07.017
10.1172/jci200319190
10.1136/ard.2007.086884
10.1096/fasebj.7.15.8262332
10.1016/s0945-053x(00)00068-8
10.1186/1476-4598-9-101
10.3892/ijo.2014.2393
10.1002/art.22174
ContentType Journal Article
Copyright Copyright © 2016 Yusheng Li et al.
Copyright © 2016 Yusheng Li et al. 2016
Copyright_xml – notice: Copyright © 2016 Yusheng Li et al.
– notice: Copyright © 2016 Yusheng Li et al. 2016
DBID ADJCN
RHU
RHW
RHX
NPM
AAYXX
CITATION
7QO
8FD
FR3
P64
7X8
5PM
DOI 10.1155/2016/6345656
DatabaseName الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals
Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Hindawi Publishing
PubMed
CrossRef
Biotechnology Research Abstracts
Technology Research Database
Engineering Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
CrossRef
Engineering Research Database
Biotechnology Research Abstracts
Technology Research Database
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
Engineering Research Database

PubMed
CrossRef
Database_xml – sequence: 1
  dbid: RHX
  name: Hindawi Publishing
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2314-6141
Editor Zhao, Yong
Editor_xml – sequence: 1
  givenname: Yong
  surname: Zhao
  fullname: Zhao, Yong
EndPage 8
ExternalDocumentID 10_1155_2016_6345656
27656654
1098440
Genre Journal Article
GrantInformation_xml – fundername: Development and Reform Commission of Hunan Province
  grantid: (2013)1199; (2014)658-8
– fundername: Science and Technology Office of Hunan Province
  grantid: 2012FJ6001, 2013SK2018
– fundername: Provincial Science Foundation of Hunan
  grantid: 14JJ3032; 2015JJ3139
– fundername: Health and Family Planning Commission of Hunan Province
  grantid: B2014-12
– fundername: Hunan Provincial Innovation Foundation for Postgraduate
  grantid: CX2016B060
– fundername: scientific and technical innovation committee of Shenzhen City
  grantid: JCYJ20150403101028191
– fundername: Valuable and Precision Instruments of Central South University
  grantid: CSUZC201639
– fundername: National Natural Science Foundation of China
  grantid: 81272034; 81402224; 81401838; 81472130
– fundername: Science and Technology Office of Changsha City
  grantid: K1203040-31
– fundername: Administration of Traditional Chinese Medicine of Hunan Province
  grantid: 2015116
– fundername: Scientific and Technical Innovation Committee of Shenzhen City
  grantid: JCYJ20150403101028191
– fundername: Central South University
  grantid: CSUZC201639
GroupedDBID 04C
24P
3V.
4.4
53G
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
AAFWJ
AAJEY
AAWTL
ABDBF
ABUWG
ACIWK
ACPRK
ADBBV
ADJCN
ADOJX
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ARAPS
BAWUL
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BMSDO
BPHCQ
BVXVI
CCPQU
CWDGH
DIK
EAD
EAP
EAS
EBD
EBS
ECF
ECT
EIHBH
EJD
EMB
EMK
EMOBN
ESX
FYUFA
GROUPED_DOAJ
H13
HCIFZ
HMCUK
HYE
IAG
IAO
IEA
IHR
INH
INR
IOF
ISR
ITC
KQ8
LK8
M1P
M48
M7P
ML0
ML~
OK1
P62
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RHX
RPM
SV3
TUS
UKHRP
RHU
RHW
NPM
AAYXX
CITATION
7QO
8FD
FR3
P64
7X8
5PM
ID FETCH-LOGICAL-c406t-a00eb314a002856d0ebce76614b3a1d44e68c39d9115707ea13c3d989a2c87213
IEDL.DBID RPM
ISSN 2314-6133
IngestDate Tue Sep 17 21:08:47 EDT 2024
Tue Aug 27 04:21:02 EDT 2024
Fri Aug 16 09:37:34 EDT 2024
Thu Sep 26 19:13:10 EDT 2024
Sat Sep 28 08:09:46 EDT 2024
Sun Jun 02 18:54:35 EDT 2024
Thu Sep 12 16:23:15 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2016
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c406t-a00eb314a002856d0ebce76614b3a1d44e68c39d9115707ea13c3d989a2c87213
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Yong Zhao
ORCID 0000-0001-9230-9053
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021466/
PMID 27656654
PQID 1827915256
PQPubID 23462
PageCount 8
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5021466
proquest_miscellaneous_1859716435
proquest_miscellaneous_1827915256
crossref_primary_10_1155_2016_6345656
pubmed_primary_27656654
hindawi_primary_10_1155_2016_6345656
emarefa_primary_1098440
PublicationCentury 2000
PublicationDate 2016-01-01
PublicationDateYYYYMMDD 2016-01-01
PublicationDate_xml – month: 01
  year: 2016
  text: 2016-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Cairo, Egypt
PublicationPlace_xml – name: Cairo, Egypt
– name: United States
PublicationTitle BioMed research international
PublicationTitleAlternate Biomed Res Int
PublicationYear 2016
Publisher Hindawi Publishing Corporation
Publisher_xml – name: Hindawi Publishing Corporation
References (14) 2000; 19
(32) 2015; 174
(38) 2014; 18
(2) 2012; 13, article 168
(33) 2015; 87
(41) 2014; 45
(42) 2015; 156
(11) 1995; 760
(40) 2010; 9, article 101
(18) 2001; 3
(15) 2010; 18
(10) 1993; 7
(30) 2015; 9
(9) 1998; 30-31
(13) 2003; 72
(37) 2014; 8
(5) 1991; 147
(19) 2002; 4
(12) 2004; 26
(28) 2013; 46
(4) 2003; 81
(1) 1999; 4
(39) 2015; 9
(20) 2009; 68
(29) 2015; 9
(34) 2013; 11
(8) 2013; 33
(23) 2001; 44
(22) 2006; 54
(7) 2003; 112
(17) 2013; 33
(21) 2011; 112
(35) 2013; 21
(3) 2014; 34
(25) 2014; 9
(6) 2000; 21
(24) 2009; 60
(16) 2009; 42
(26) 2014; 16
(31) 2015; 24
(36) 2013; 52
(27) 2013; 2013
11879535 - Arthritis Res. 2002;4(1):30-5
9893260 - J Cell Biochem Suppl. 1998;30-31:92-102
1918998 - J Immunol. 1991 Nov 1;147(9):2902-6
25533241 - Clin Immunol. 2015 Feb;156(2):141-53
24807695 - Rheumatol Int. 2014 Dec;34(12):1627-31
10936449 - Matrix Biol. 2000 Jul;19(3):245-55
8262332 - FASEB J. 1993 Dec;7(15):1475-82
26232502 - Microb Pathog. 2015 Oct;87:59-68
26136997 - Exp Ther Med. 2015 Jun;9(6):2415-2419
22954354 - BMC Musculoskelet Disord. 2012 Sep 07;13:168
21815191 - J Cell Biochem. 2011 Dec;112(12 ):3507-14
24503399 - Zhonghua Nei Ke Za Zhi. 2013 Dec;52(12):1023-7
12865402 - J Clin Invest. 2003 Jul;112(2):147-9
26136925 - Exp Ther Med. 2015 May;9(5):1979-1983
18662930 - Ann Rheum Dis. 2009 Jun;68(6):1051-8
24505477 - PLoS One. 2014 Feb 05;9(2):e88335
24756245 - Int J Oncol. 2014 Jul;45(1):282-90
25481537 - Int Immunopharmacol. 2015 Jan;24(1):95-101
25267358 - Microbes Infect. 2014 Nov;16(11):954-61
11714388 - Arthritis Res. 2001;3(6):342-7
26136936 - Exp Ther Med. 2015 Jun;9(6):2059-2064
23132541 - Rheumatol Int. 2013 May;33(5):1313-9
15494684 - Exp Oncol. 2004 Sep;26(3):179-84
17075858 - Arthritis Rheum. 2006 Nov;54(11):3533-44
19217889 - Clin Biochem. 2009 Jun;42(9):808-12
23025929 - Osteoarthritis Cartilage. 2013 Jan;21(1):144-50
14710506 - Bull World Health Organ. 2003;81(9):646-56
7785896 - Ann N Y Acad Sci. 1995 Apr 21;760:223-41
26231448 - J Ethnopharmacol. 2015 Nov 4;174:37-44
23331101 - Int Endod J. 2013 Jul;46(7):666-74
11263773 - Arthritis Rheum. 2001 Mar;44(3):585-94
11071524 - Immunol Today. 2000 Oct;21(10 ):475-8
19747583 - Osteoarthritis Cartilage. 2010 Jan;18(1):82-7
19644889 - Arthritis Rheum. 2009 Aug;60(8):2362-71
25535126 - Eur Rev Med Pharmacol Sci. 2014;18(23):3580-6
12469249 - Calcif Tissue Int. 2003 Mar;72(3):197-205
20459645 - Mol Cancer. 2010 May 07;9:101
25009588 - Exp Ther Med. 2014 Aug;8(2):391-394
22218639 - Rheumatol Int. 2013 Jan;33(1):79-83
10525481 - Front Biosci. 1999 Oct 15;4:D662-70
24302816 - Mediators Inflamm. 2013;2013:596716
22
24
25
27
28
29
30
31
32
11
33
13
35
14
15
37
16
17
39
18
19
1
2
6
7
8
40
41
20
42
21
References_xml – volume: 760
  start-page: 223
  year: 1995
  end-page: 241
  ident: 11
  article-title: Regulation of osteopontin expression in osteoblasts
  publication-title:
– volume: 8
  start-page: 391
  issue: 2
  year: 2014
  end-page: 394
  ident: 37
  article-title: Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro
  publication-title:
– volume: 33
  start-page: 1313
  issue: 5
  year: 2013
  end-page: 1319
  ident: 17
  article-title: Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13
  publication-title:
– volume: 3
  start-page: 342
  issue: 6
  year: 2001
  end-page: 347
  ident: 18
  article-title: Articular cartilage and changes in arthritis: noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage
  publication-title:
– volume: 54
  start-page: 3533
  issue: 11
  year: 2006
  end-page: 3544
  ident: 22
  article-title: Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
  publication-title:
– volume: 4
  start-page: 30
  issue: 1
  year: 2002
  end-page: 35
  ident: 19
  article-title: Collagen of articular cartilage
  publication-title:
– volume: 112
  start-page: 3507
  issue: 12
  year: 2011
  end-page: 3514
  ident: 21
  article-title: ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis
  publication-title:
– volume: 18
  start-page: 82
  issue: 1
  year: 2010
  end-page: 87
  ident: 15
  article-title: Elevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patients
  publication-title:
– volume: 81
  start-page: 646
  issue: 9
  year: 2003
  end-page: 656
  ident: 4
  article-title: Burden of major musculoskeletal conditions
  publication-title:
– volume: 68
  start-page: 1051
  issue: 6
  year: 2009
  end-page: 1058
  ident: 20
  article-title: Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
  publication-title:
– volume: 30-31
  start-page: 92
  issue: 31
  year: 1998
  end-page: 102
  ident: 9
  article-title: Osteopontin expression and function: role in bone remodeling
  publication-title:
– volume: 26
  start-page: 179
  issue: 3
  year: 2004
  end-page: 184
  ident: 12
  article-title: Role of osteopontin in adhesion, migration, cell survival and bone remodeling
  publication-title:
– volume: 42
  start-page: 808
  issue: 9
  year: 2009
  end-page: 812
  ident: 16
  article-title: Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis
  publication-title:
– volume: 9
  start-page: 2415
  issue: 6
  year: 2015
  end-page: 2419
  ident: 29
  article-title: Osteopontin inhibits HIF-2 mRNA expression in osteoarthritic chondrocytes
  publication-title:
– volume: 24
  start-page: 95
  issue: 1
  year: 2015
  end-page: 101
  ident: 31
  article-title: PRMT6 mediates CSE induced inflammation and apoptosis
  publication-title:
– volume: 87
  start-page: 59
  year: 2015
  end-page: 68
  ident: 33
  article-title: Strategies of NF- B signaling modulation by ectromelia virus in BALB/3T3 murine fibroblasts
  publication-title:
– volume: 112
  start-page: 147
  issue: 2
  year: 2003
  end-page: 149
  ident: 7
  article-title: Osteopontin: a bridge between bone and the immune system
  publication-title:
– volume: 13, article 168
  year: 2012
  ident: 2
  article-title: A prospective study of the impact of musculoskeletal pain and radiographic osteoarthritis on health related quality of life in community dwelling older people
  publication-title:
– volume: 11
  start-page: 315
  issue: 2
  year: 2013
  end-page: 326
  ident: 34
  article-title: Glutamine on intestinal inflammation: a mechanistic perspective
  publication-title:
– volume: 7
  start-page: 1475
  issue: 15
  year: 1993
  end-page: 1482
  ident: 10
  article-title: Osteopontin: a protein with diverse functions
  publication-title:
– volume: 33
  start-page: 79
  issue: 1
  year: 2013
  end-page: 83
  ident: 8
  article-title: The effect of hyaluronic acid on osteopontin and CD44 mRNA of fibroblast-like synoviocytes in patients with osteoarthritis of the knee
  publication-title:
– volume: 174
  start-page: 37
  year: 2015
  end-page: 44
  ident: 32
  article-title: Ethanol extract of and saikosaponins inhibit neuroinflammation via inhibition of NF- B
  publication-title:
– volume: 60
  start-page: 2362
  issue: 8
  year: 2009
  end-page: 2371
  ident: 24
  article-title: Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice
  publication-title:
– volume: 156
  start-page: 141
  issue: 2
  year: 2015
  end-page: 153
  ident: 42
  article-title: Pristane primed rat T cells enhance TLR3 expression of fibroblast-like synoviocytes via TNF- initiated p38 MAPK and NF- B pathways
  publication-title:
– volume: 147
  start-page: 2902
  issue: 9
  year: 1991
  end-page: 2906
  ident: 5
  article-title: Polyclonal B cell activation by the Eta-1 cytokine and the development of systemic autoimmune disease
  publication-title:
– volume: 2013
  year: 2013
  end-page: 10
  ident: 27
  article-title: HMGB1 acts in synergy with lipopolysaccharide in activating rheumatoid synovial fibroblasts via p38 MAPK and NF- B signaling pathways
  publication-title:
– volume: 4
  start-page: D662
  year: 1999
  end-page: D670
  ident: 1
  article-title: An introduction to the pathophysiology of osteoarthritis
  publication-title:
– volume: 46
  start-page: 666
  issue: 7
  year: 2013
  end-page: 674
  ident: 28
  article-title: CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF- B signalling pathways in odontoblast cells
  publication-title:
– volume: 9
  start-page: 2059
  issue: 6
  year: 2015
  end-page: 2064
  ident: 39
  article-title: Correlation between osteopontin and caveolin-1 in the pathogenesis and progression of osteoarthritis
  publication-title:
– volume: 21
  start-page: 475
  issue: 10
  year: 2000
  end-page: 478
  ident: 6
  article-title: Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks
  publication-title:
– volume: 52
  start-page: 1023
  year: 2013
  end-page: 1027
  ident: 36
  article-title: The clinical significance of serum and joint fluid osteopontin, and thrombin-cleaved osteopontin levels in osteoarthritis
  publication-title:
– volume: 18
  start-page: 3580
  issue: 23
  year: 2014
  end-page: 3586
  ident: 38
  article-title: Effects of osteopontin on the expression of IL-6 and IL-8 inflammatory factors in human knee osteoarthritis chondrocytes
  publication-title:
– volume: 9, article 101
  year: 2010
  ident: 40
  article-title: Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF- B dependent AP-1-mediated ICAM-1 expression in breast cancer cells
  publication-title:
– volume: 34
  start-page: 1627
  year: 2014
  end-page: 1631
  ident: 3
  article-title: Association of osteopontin with osteoarthritis
  publication-title:
– volume: 45
  start-page: 282
  issue: 1
  year: 2014
  end-page: 290
  ident: 41
  article-title: Osteopontin promotes the progression of gastric cancer through the NF- B pathway regulated by the MAPK and PI3K
  publication-title:
– volume: 21
  start-page: 144
  issue: 1
  year: 2013
  end-page: 150
  ident: 35
  article-title: Usefulness of specific OA biomarkers, thrombin-cleaved osteopontin, in the posterior cruciate ligament OA rabbit model
  publication-title:
– volume: 44
  start-page: 585
  issue: 3
  year: 2001
  end-page: 594
  ident: 23
  article-title: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes
  publication-title:
– volume: 9
  start-page: 1979
  issue: 5
  year: 2015
  end-page: 1983
  ident: 30
  article-title: Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee osteoarthritis
  publication-title:
– volume: 72
  start-page: 197
  issue: 3
  year: 2003
  end-page: 205
  ident: 13
  article-title: The integrin and CD44 regulate the actions of osteopontin on osteoclast motility
  publication-title:
– volume: 19
  start-page: 245
  issue: 3
  year: 2000
  end-page: 255
  ident: 14
  article-title: Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage
  publication-title:
– volume: 9
  issue: 2
  year: 2014
  ident: 25
  article-title: Serum amino acids profile and the beneficial effects of L-arginine or L-glutamine supplementation in dextran sulfate sodium colitis
  publication-title:
– volume: 16
  issue: 11
  year: 2014
  ident: 26
  article-title: Mouse jejunum innate immune responses altered by enterotoxigenic Escherichia coli (ETEC) infection
  publication-title:
– ident: 18
  doi: 10.1186/ar326
– ident: 15
  doi: 10.1016/j.joca.2009.07.009
– ident: 17
  doi: 10.1007/s00296-012-2548-4
– ident: 32
  doi: 10.1016/j.jep.2015.07.039
– volume: 18
  start-page: 3580
  issue: 23
  year: 2014
  ident: 38
  publication-title: European Review for Medical and Pharmacological Sciences
– volume: 81
  start-page: 646
  issue: 9
  year: 2003
  ident: 4
  publication-title: Bulletin of the World Health Organization
– volume: 11
  start-page: 315
  issue: 2
  year: 2013
  ident: 34
  publication-title: European Journal of Inflammation
  doi: 10.1177/1721727X1301100201
– ident: 37
  doi: 10.3892/etm.2014.1750
– ident: 30
  doi: 10.3892/etm.2015.2310
– volume: 34
  start-page: 1627
  year: 2014
  ident: 3
  publication-title: Rheumatology International
  doi: 10.1007/s00296-014-3036-9
– ident: 11
  doi: 10.1111/j.1749-6632.1995.tb44633.x
– ident: 42
  doi: 10.1016/j.clim.2014.11.008
– ident: 31
  doi: 10.1016/j.intimp.2014.10.029
– volume: 52
  start-page: 1023
  year: 2013
  ident: 36
  publication-title: Zhonghua Nei Ke Za Zhi
– ident: 24
  doi: 10.1002/art.24705
– volume: 30-31
  start-page: 92
  issue: 31
  year: 1998
  ident: 9
  publication-title: Journal of Cellular Biochemistry
– volume: 16
  issue: 11
  year: 2014
  ident: 26
  publication-title: Microbes and Infection
– ident: 25
  doi: 10.1371/journal.pone.0088335
– ident: 39
  doi: 10.3892/etm.2015.2433
– ident: 1
  doi: 10.2741/a463
– ident: 16
  doi: 10.1016/j.clinbiochem.2009.02.002
– ident: 35
  doi: 10.1016/j.joca.2012.09.006
– ident: 2
  doi: 10.1186/1471-2474-13-168
– volume: 44
  start-page: 585
  issue: 3
  year: 2001
  ident: 23
  publication-title: Arthritis and Rheumatism
  doi: 10.1002/1529-0131(200103)44:3<585::AID-ANR107>3.0.CO;2-C
– ident: 28
  doi: 10.1111/iej.12043
– ident: 19
  doi: 10.1186/ar380
– ident: 6
  doi: 10.1016/s0167-5699(00)01715-1
– ident: 27
  doi: 10.1155/2013/596716
– ident: 13
  doi: 10.1007/s00223-002-1025-6
– volume: 147
  start-page: 2902
  issue: 9
  year: 1991
  ident: 5
  publication-title: Journal of Immunology
  doi: 10.4049/jimmunol.147.9.2902
– ident: 8
  doi: 10.1007/s00296-011-2339-3
– ident: 21
  doi: 10.1002/jcb.23298
– ident: 29
  doi: 10.3892/etm.2015.2434
– ident: 33
  doi: 10.1016/j.micpath.2015.07.017
– ident: 7
  doi: 10.1172/jci200319190
– volume: 26
  start-page: 179
  issue: 3
  year: 2004
  ident: 12
  publication-title: Experimental Oncology
– ident: 20
  doi: 10.1136/ard.2007.086884
– volume: 7
  start-page: 1475
  issue: 15
  year: 1993
  ident: 10
  publication-title: FASEB Journal
  doi: 10.1096/fasebj.7.15.8262332
– ident: 14
  doi: 10.1016/s0945-053x(00)00068-8
– ident: 40
  doi: 10.1186/1476-4598-9-101
– ident: 41
  doi: 10.3892/ijo.2014.2393
– ident: 22
  doi: 10.1002/art.22174
SSID ssj0000816096
Score 2.2618117
Snippet Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown....
SourceID pubmedcentral
proquest
crossref
pubmed
hindawi
emarefa
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1
SummonAdditionalLinks – databaseName: Hindawi Publishing
  dbid: RHX
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bS8MwFA46UHwR784bEfSx2C6Xto8qG0OYihfYW0mb1PXBdriJ_jZ_hL_Jc9JsOBX1qQ1N0zYn5TtfzuE7hByZONAyTZnXkrnv8VBxL9U89UQW5uhR6DzHfcjepeze84u-6DuRpNH3ED6gHdDzQJ5IZl2PeTIfRSiRf9PtT7dSsHaEH9dl5AIOZIixSYr7l9tnwGfBPCo4AURaGCD_fSl-8jK_Jkt-Qp_OCll2biM9re28SuZMuUYWey4wvk6KK7BWNayw7gO9til2ZkTbry7NtaRVTnuoxv9Ke2aMwXYr0FCUAGI0YNSV66GXHe_97YzeFg_ooJcPFIazQ8MKG1j9ow1y32nfnXc9V0XBywCsx57yfSDMAVdIr4TU0MpMiLCcMhVozo2MMhbrGGV3_NCogGVMx1GsWlkE_JBtkkZZlWab0CjK4B9WqW5pxpVRKTMMDlIA0Eoj8iY5nkxvMqzFMhJLMoRI0AyJM0OTbLm5_9Qtjjj3m-TI2eKPAQ4nhkrgd8AYhypN9TxKgC6FMdZ0-rWPQOEscBThRWrjTp_WCtHBFbxJwhmzTzugHPfslbIYWFluYYuky53_fcIuWcJmvZuzRxrjp2ezD_7NOD2wq_sDnL70mA
  priority: 102
  providerName: Hindawi Publishing
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3bTtwwEB1RKipeEG0pLJfKSPCYksSXJA8I0YoVQgqtVFbiLXJiZzdSm1B2Ube_1o_oN3XG60UsQrRPSRTHTnzszDn2aAbgwGaRUWXJg1jVYSASLYLSiDKQVVITozB1TeuQ-aU6H4iLa3m9BPNso74Dx09KO8onNbj99mH649cJTvhjN-GlRP0eqSPFHTd5AS9jwQWN9dwTffdPTiOFZH3u-f7ooQWbtGK_azxBQ7UyIln8s3mKfD72oXxglPrrsObZJDudwf8almz7Bl7lfr_8LTSfEcTupqN0EOyL87yzY3Y29d6vLetqllOQ_inL7YT24F3chqZF28YiznwWH3bZD_78_si-NkPi7e2QYXWuahx4IxcWaQMG_bOrT-eBT64QVGjDJ4EOQ9TRkdCkuqQyeFXZhKx1yXVkhLAqrXhmMorGEyZWR7ziJkszHVcpykb-DpbbrrVbwNK0wqmtSxMbLrTVJbccD0qi_VVW1j04nHdvcTOLoVE47SFlQTAUHoYebPq-f1AsS4UIe3DgsfhHBftzoAqcJbT1oVvb3Y0LVFFJRqmeni0jKZ4W8kd8kRm4963FCfFeKXqQLMB-X4CidC_eaZuRi9YtXe50tf0f7e7AKn3ObIVnF5Ynt3d2DznPpHzvhvNfh7kA4A
  priority: 102
  providerName: Scholars Portal
Title Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis
URI https://search.emarefa.net/detail/BIM-1098440
https://dx.doi.org/10.1155/2016/6345656
https://www.ncbi.nlm.nih.gov/pubmed/27656654
https://search.proquest.com/docview/1827915256
https://search.proquest.com/docview/1859716435
https://pubmed.ncbi.nlm.nih.gov/PMC5021466
Volume 2016
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3datswFBZtR0dvRvfXZWuDBt2lGzv6sX25lmRh4Cx0K-TOSJbcGBY5tCnrs-0h9kw7R7ZLUsYGu5EtLMuyjuRzPun4O4Sc2jQyUmsWDGUZBjxWPNCG60AUcYkWhSlLXIfMpnJyxT_PxXyHiO5fGO-0X-jqzH1fnrlq4X0rV8ti0PmJDWbZhfDhqOVgl-zGjG1AdP_5TSIZpk1QuYgDNGKsc3gXArB-JAeSeTsGiYBjtGcE39JK-3ap4ARU1f4CgfGP6k_m52Mvyg21ND4kz1p7kn5s2v2c7Fj3gjzN2h3zl6T6AmKsVzUGhKAz73tnb-novvV_dbQuaYY0_fc0s2vchffMDZUD7UYjRts4PnQ6Dn79PKdfq2u03N01hep81dBjC0-M9IpcjUffLiZBG14hKECLrwMVhoCkI64QdwlpIFfYGPW1ZioynFuZFCw1KfLxhLFVESuYSZNUDYsEgCN7TfZc7ewbQpOkgMmttBkaxpVVmlkGBylAA0sryh750HVvvmpYNHKPPoTIUSJ5K5EeOWr7fqNYmnAe9shpK4t_VPC-E1QO8wQ3P5Sz9d1tDjgqTjHY01_LCGTUAgsSGtII9-Fp3UjpkXhL7A8FkKd7-woMX8_X3Q7Xt_995ztygC_ZrPwck731zZ09AVtorfswA-YxpMn4U588OR9NZ5eQy3gC6eVk3vdz4ze5GA0a
link.rule.ids 230,315,733,786,790,869,884,891,2236,24346,27955,27956,31753,33407,33778,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtNAEB2VogIv3C_hukjl0Ymdvdh-hKpRgDpUokV9s_bmxoLYEXVExafxEXwTs2u7SioEgifb8nrt1cx6zvGOzwDs2jQyQikajEURBiyWLFCGqYDruHCIwhSF-w6ZzcT0mL074SdbwPt_YXzSvlblsPqyGFbl3OdWLhd61OeJjQ6zPe7LUYvRFbiK83XM10i6fwEnkQjTtqxcxJAcUdqnvHOObD8SI0E9knFSwLFDNJxtxKUdu5C4g8FqZ-6o8bfydwD0ch7lWmCa3IJP_ZDafJTPw1Wjhvr7JbXHfx7zbbjZQVXyuj19B7ZsdReuZd1i_D0oP6CH1Mva1Zoghz6tz56R_fMutbYidUEyVwHgnGS2cQv8XhSirDBwkoiSrkQQmU2Cnz_ekI_lqSMF1SnB7nzX-GBzr7l0H44n-0d706Cr3BBoBAhNIMMQSXrEpKN0XBg80jZ2UEBRGRnGrEg0TU3qpH7C2MqIamrSJJVjnSAnpQ9gu6or-whIkmh8b0hlxoYyaaWiluJGcAzuwvJiAK96u-XLVqAj98SG89yZOu9MPYCHnVHXmqUJY-EAdjsj_6WDl70H5DgF3bqKrGy9OsuRosWpqyP1xzbciXUhOMUHab3m4m69Cw4g3vCniwZOAnzzDHqJlwLvvOLxf1_5Aq5Pj7KD_ODt7P0TuOEG3H5gegrbzdeVfYaQq1HP_QT7BcVUKbQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3batwwEBVtSkJeem-zvaqQPnptry62H9M0S3rxdqENhL4Y3Zw1ydpL46Whn9aPyDd1JMthN5QW8mQby7LFjDznSMMZhHZNFmsuJQlGvIwCmggaSE1lwFRSWkShy9KuQ-YTfnhEPx6z45VSXy5pX8lqWJ_Nh3U1c7mVi7kK-zyxcJrvM1eOmocLXYa30R2Ys6Nkhai7n3Aa8yjrSsvFFAgSIX3aO2PA-GMecuLQjJUDTiyqYXQtNm2auYATCFibM0uPf1Z_A6HXcylXgtP4HvreD6vLSTkdLls5VL-uKT7eaNz30V0PWfFe1-QBumXqh2gr95vyj1D1BTylWTS25gSeuvQ-c44PLnyKbY2bEue2EsAFzk1rN_qdOERVQwDFMcG-VBCejIPL3-_w1-rEkoP6BEN3rmv4uJnTXnqMjsYH3_YPA1_BIVAAFNpARBGQ9ZgKS-0Y13ClTGIhgSQi1pQaniqS6cxK_kSJETFRRGdpJkYqBW5KnqCNuqnNDsJpquD_IaQeaUKFEZIYAgfOIMhzw8oBetvbrlh0Qh2FIziMFdbchTf3AD31hl1plqWURgO06w39nw7e9F5QwFS0-yuiNs3yvACqlmS2ntQ_2zAr2gUgFT6k85yrt_VuOEDJmk9dNbBS4Ot3wFOcJLj3jGc3fvI12pq-HxefP0w-PUfbdrzdOtMLtNH-WJqXgLxa-crNsT8WvCw0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Osteopontin+Promotes+Expression+of+Matrix+Metalloproteinase+13+through+NF-%CE%BAB+Signaling+in+Osteoarthritis&rft.jtitle=BioMed+research+international&rft.au=Li%2C+Yusheng&rft.au=Jiang%2C+Wei&rft.au=Wang%2C+Hua&rft.au=Deng%2C+Zhenhan&rft.date=2016-01-01&rft.eissn=2314-6141&rft.volume=2016&rft.spage=6345656&rft.epage=6345656&rft_id=info:doi/10.1155%2F2016%2F6345656&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2314-6133&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2314-6133&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2314-6133&client=summon