A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy

Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supra...

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Bibliographic Details
Published inTheranostics Vol. 12; no. 1; pp. 396 - 409
Main Authors Zhang, Tian-Xing, Hou, Xiaoxue, Kong, Yong, Yang, Fan, Yue, Yu-Xin, Shah, Muhammad Raza, Li, Hua-Bin, Huang, Fan, Liu, Jianfeng, Guo, Dong-Sheng
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 2022
Ivyspring International Publisher
Subjects
Animals
Cancer
Cell Line, Tumor
Dyes
Hypoxia
Hypoxia - metabolism
Mice
Nanomaterials
Neoplasms - therapy
Photochemotherapy - methods
Photothermal Therapy - methods
Reproducibility
Research Paper
Theranostic Nanomedicine - methods
hypoxia
IR780
calixarene
supramolecular chemistry
photothermal therapy
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ISSN1838-7640
1838-7640
DOI10.7150/thno.67036

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Summary:Photothermal agents (PTAs) based on organic small-molecule dyes emerge as promising theranostic strategy in imaging and photothermal therapy (PTT). However, hydrophobicity, photodegradation, and low signal-to-noise ratio impede their transformation from bench to bedside. In this study, a novel supramolecular PTT formulation by a stimuli-responsive macrocyclic host is prepared to overcome these obstacles of organic small-molecule PTAs. Sulfonated azocalix[4]arene (SAC4A) was synthesized as a hypoxia-responsive macrocyclic host. Taking IR780 as an example, the supramolecular nanoformulation IR780@SAC4A was constructed by grinding method, and its solubility, photostability, and photothermal conversion were evaluated. The hypoxia tumor-selective imaging and supramolecular PTT of IR780@SAC4A were further evaluated and . IR780@SAC4A is capable of enhancing the solubility, photostability, and photothermal conversion of IR780 significantly, which achieve this supramolecular formulation with good imaging-guided PTT efficacy and . This study demonstrates that the supramolecular PTT strategy is a promising cancer theranostic method. Moreover, this supramolecular approach is applicative to construct kinds of supramolecular PTAs, opening a general avenue for extending smart PTT formulations.
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These authors contributed equally to this work.
Competing Interests: The authors have declared that no competing interest exists.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.67036