Synthesis of Novel 3,7-Dihydro-purine-2,6-dione Derivatives

Forty-six novel 3,7-dihydro-purine-2,6-dione derivatives (substituted xanthines) with great structural diversity were synthesized for biological activity screening. Three series of substituted xanthine analogs have been prepared in moderate to excellent yields.

Saved in:
Bibliographic Details
Published inSynthetic communications Vol. 40; no. 10; pp. 1418 - 1436
Main Authors Liu, Gang, Reddy, P. S. Murali Mohan, Barber, Jack R., Ng, Shi Chung, Zhou, Yuefen
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.01.2010
Taylor & Francis
Taylor & Francis Ltd
Subjects
3,7-dihydro-purine-2,6-dione derivatives
Analog synthesis for biological screening
Chemistry
Chemistry, Organic
Derivatives
Physical Sciences
Science & Technology
substituted xanthines
xanthine derivatives
7-dihydro-purine-2
6-dione derivatives
ADENOSINE RECEPTORS
POTENT
3
ANALOGS
xanthine derivatives
substituted xanthines
CAFFEINE
Analog synthesis for biological screening
ANTAGONISTS
Online AccessGet full text

Cover

More Information
Summary:Forty-six novel 3,7-dihydro-purine-2,6-dione derivatives (substituted xanthines) with great structural diversity were synthesized for biological activity screening. Three series of substituted xanthine analogs have been prepared in moderate to excellent yields.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910903097260