Transmitted HIV Drug Resistance Among Drug-Naive Subjects Recently Infected With HIV in Mexico City: A World Health Organization Survey to Classify Resistance and to Field Test Two Alternative Patient Enrollment Methods

• Published in: Clinical infectious diseases Vol. 54; no. suppl_4; pp. S328 - S333
• Main Authors: Bertagnolio, Silvia, Rodriguez-Diaz, Roberto A., Fuentes-Romero, Luis L., Bennett, Diane E., Viveros-Rogel, Monica, Hart, Stephen, Pilon, Richard, Sandstrom, Paul, Soto-Ramirez, Luis E.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 15.05.2012
• Subjects: Adolescent; Adult; Comparative analysis; Counseling; Cross-Sectional Studies; Data Collection; Datasets; Disease transmission; Drug and alcohol surveys; Drug resistance; Drug Resistance, Viral; Female; Health Surveys - economics; Health Surveys - methods; HIV; HIV - classification; HIV - drug effects; HIV - genetics; HIV infections; HIV Infections - epidemiology; HIV Infections - virology; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Labor force surveys; Male; Mexico - epidemiology; Patient Selection; Population Surveillance; Questionnaires; Reverse Transcriptase Inhibitors - pharmacology; Specimens; World Health Organization; Mexico; Mexico, Distrito Federal, Mexico City
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/cid/cir938

In 2004, the World Health Organization performed a survey to assess transmitted drug resistance in Mexico City among drug-naive persons with newly diagnosed human immunodeficiency virus (HIV) infection and likely to be recently infected who were attending 3 voluntary counseling and testing sites. A parallel study comparing 2 alternative methods of enrolling survey participant was conducted in 9 voluntary counseling and testing sites in central Mexico. In study arm 1, subject information, consent and blood specimens were obtained during the HIV diagnostic testing visit. In study arm 2, consent and blood specimens were obtained at the return visit, only from those who were HIV infected. This survey classified nonnucleoside reverse-transcriptase inhibitor and nucleoside reverse-transcriptase inhibitor transmitted drug resistance as <5% and 5%—15%, respectively. Arm 2 yielded major advantages in cost and workload, with no evidence of increased sampling bias.