The value of quantitative magnetic resonance imaging signal intensity in distinguishing between spinal meningiomas and schwannomas

• Published in: International journal of medical sciences Vol. 19; no. 7; pp. 1110 - 1117
• Main Authors: Hung, Nguyen Duy, Dung, Le Thanh, Huyen, Dang Khanh, Duy, Ngo Quang, He, Dong-Van, Duc, Nguyen Minh
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher Pty Ltd 01.01.2022; Ivyspring International Publisher
• Subjects: Bone cancer; Brain cancer; Confidence intervals; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mann-Whitney U test; Meningeal Neoplasms - diagnostic imaging; Meningioma - diagnostic imaging; Neurilemmoma - diagnostic imaging; Neurilemmoma - surgery; Pathology; Patients; Qualitative research; Research Paper; Retrospective Studies; Spinal cancer; Statistical analysis; Tumors; meningioma; quantitative measurement; magnetic resonance imaging; schwannoma; spinal tumor
• ISSN: 1449-1907; 1449-1907
• DOI: 10.7150/ijms.73319

Prior studies have suggested a number of the subjective visual characteristics that help distinguish between spinal meningiomas and schwannomas on magnetic resonance imaging and computed tomography; however, objective quantification of the signal intensity can be useful information. This study assessed whether quantitative magnetic resonance imaging (MRI) signal intensity (SI) measurements could distinguish intradural-extramedullary schwannomas from meningiomas. From July 2019 to September 2021, 54 patients with intradural-extramedullary tumors (37 meningiomas and 17 schwannomas) underwent surgery, and tumors were verified pathologically. Defined regions of interest were used to quantify SI values on T1- (T1W) and T2-weighted images (T2W). Receiver operating characteristic curve analysis was used to obtain cutoff values and calculate the area under the curve (AUC), sensitivity (SE), specificity (SP), positive predictive value (PPV), and negative predictive value (NPV). Both Maximum (T2 ) and mean (T2 ) T2W SI values demonstrated outstanding (AUC: 0.91) abilities to differentiate meningiomas from schwannomas with Se, Sp, PPV, and NPV values of 94.6%, 70.6%, 87.5%, and 85.7%, respectively, for T2 and 81.1%, 88.2%, 93.8%, and 68.2% for T2 . The maximum SI value on contrast-enhanced T1W (T1CE ) and the T2W tumor: fat SI ratio (rTF) demonstrated acceptable abilities (AUC: 0.73 and 0.79, respectively) to differentiate meningiomas from schwannomas with Se, Sp, PPV, and NPV values of 94.6%, 70.6%, 87.5%, and 85.7%, respectively, for T1CE and 81.1%, 88.2%, 93.8%, and 68.2% for rTF. Quantitative SI values (T2 , T2 T2 , T1CE , rTF) can be used to differentiate intradural-extramedullary schwannomas from meningiomas.