Transport of cesium and potassium ions across bilayer lipid membranes — Cesium accumulation in biological cells according to the membrane potential

• Published in: Journal of electroanalytical chemistry (Lausanne, Switzerland) Vol. 779; pp. 131 - 136
• Main Authors: Kimura, Keisuke, Shirai, Osamu, Kitazumi, Yuki, Kano, Kenji
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.10.2016; Elsevier Science Ltd
• Subjects: Anions; Bilayer lipid membrane; Bioaccumulation; Cesium; Counter anion; Hydrophobic surfaces; Hydrophobicity; Ion transport; Phases; Potassium; Voltammetry; Bilayer lipid membrane; Ion transport; Cesium; Voltammetry; Hydrophobicity; Potassium; Counter anion
• ISSN: 1572-6657; 1873-2569
• DOI: 10.1016/j.jelechem.2016.04.007

The transport of Cs+ across a bilayer lipid membrane between two aqueous phases containing chloride and perchlorate salts was readily observed when compared to using K+, because Cs+ is more hydrophobic than K+. After the Cs+ was distributed from the aqueous to the BLM with a counter anion, such as Cl− and ClO4−, the antiport of Cs+ and the counter anion across the bilayer lipid membrane was caused by applying the potential difference between the two aqueous phases. By comparing the permeability in the presence of chloride salts with that in the presence of perchlorate salts, it can be appreciated that the standard potential for the transport of Cs+ from the aqueous phase to the bilayer lipid membrane is about 60mV more negative than that of K+. According to the ion transport mechanism, the accumulation of Cs+ within living cells is assumed to be caused by the membrane potential, which is mainly generated by the transport of K+ across the cell membrane between the outside and inside. By use of a liquid membrane cell, it was verified that the membrane potential generated by the concentration ratio of K+ between two aqueous phases caused the accumulation of Cs+. [Display omitted] •The standard potential for the transport of Cs+ from the aqueous phase to the bilayer lipid membrane is about 60mV more negative than that of K+.•By considering the ratio of the diffusion coefficient of Cs+ in the BLM to that of K+, it is predictable that Cs+ and K+ exist as non-hydrated ions within the BLM.•The accumulation of Cs+ within living cells is assumed to be caused by the membrane potential generated by the transport of K+.