Effect of somatostatin analog octreotide on human sphincter of Oddi

The effect of the long-acting somatostatin analog octreotide on the sphincter of Oddi was investigated in seven subjects referred for endoscopic sphincter of Oddi manometry. Six patients had unexplained right upper quadrant pain and one had bile duct dilatation without evidence of fixed obstruction...

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Bibliographic Details
Published inDigestive diseases and sciences Vol. 37; no. 5; p. 773
Main Authors Binmoeller, K F, Dumas, R, Harris, A G, Delmont, J P
Format Journal Article
LanguageEnglish
Published United States 01.05.1992
Subjects
Adult
Catheterization - instrumentation
Endoscopy, Digestive System - instrumentation
Endoscopy, Digestive System - methods
Female
Humans
Male
Manometry - instrumentation
Manometry - methods
Middle Aged
Octreotide - pharmacology
Sphincter of Oddi - drug effects
Sphincter of Oddi - physiology
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Summary:The effect of the long-acting somatostatin analog octreotide on the sphincter of Oddi was investigated in seven subjects referred for endoscopic sphincter of Oddi manometry. Six patients had unexplained right upper quadrant pain and one had bile duct dilatation without evidence of fixed obstruction on endoscopic retrograde cholangiopancreatography. A triple-lumen low-compliance system was used to record the sphincter of Oddi basal pressure, phasic contraction frequency, amplitude, duration, and direction of wave propagation before and after intravenous administration of octreotide in a dose of 50 micrograms. After a mean latency period of 1 min, significant changes included increased basal pressure in all seven patients, increased frequency of wave contractions in six patients, and decreased wave amplitude in six patients. The median duration of wave contraction and wave propagation sequence were not significantly influenced. Thus, octreotide has a significant stimulatory affect on the sphincter of Oddi activity, which may impair biliary and pancreatic flow.
ISSN:0163-2116
DOI:10.1007/bf01296438