Salivary biomarkers for the detection of malignant tumors that are remote from the oral cavity

Proteomic analyses by mass spectrometry are propelling the field of medical diagnostics forward at unprecedented rates because of its ability reliably to identify proteins that are at the femtomole level in concentration. These advancements have also benefited biomarker research to the point where s...

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Bibliographic Details
Published inClinics in laboratory medicine Vol. 29; no. 1; p. 71
Main Authors Bigler, Lenora R, Streckfus, Charles F, Dubinsky, William P
Format Journal Article
LanguageEnglish
Published United States 01.03.2009
Subjects
Biomarkers, Tumor - analysis
Breast Neoplasms - diagnosis
Chromatography, Liquid
Female
Humans
Mass Spectrometry
Protein Array Analysis
Saliva - chemistry
Signal Transduction
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Summary:Proteomic analyses by mass spectrometry are propelling the field of medical diagnostics forward at unprecedented rates because of its ability reliably to identify proteins that are at the femtomole level in concentration. These advancements have also benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of malignant tumors that are remote from the oral cavity. Saliva is easy to collect and may provide diagnostic information about a variety of cancers. In particular, proof-of-principle has been demonstrated for salivary biomarker research. This article reviews the literature, discusses the theories associated with saliva-based tumor diagnostics, and presents the current research focused on the use of saliva as a diagnostic medium for the detection of cancer.
ISSN:1557-9832
DOI:10.1016/j.cll.2009.01.004