Mutagenicity Screening of Water Extracts from Crude Drugs and Quercetin as Mutagenic Component

Water extracts of 41 commercial crude drugs were subjected to screening studies for mutagenicity by means of the reversion assay with Ames'strain TA 98 and TA 100 of Salmonella typhimurium. Ten of the water extracts were found to be positive in the Ames test. In general, these observed mutageni...

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Published inEisei Kagaku Vol. 40; no. 1; pp. 66 - 70
Main Authors NOZAKA, TOMIO, YAMADA, SAYURI, HIROSE, YOSIFUMI, ISHINO, MASAZO, TANAKA, AKIO
Format Journal Article Conference Proceeding
LanguageEnglish
Japanese
Published Tokyo The Pharmaceutical Society of Japan 1994
Nippon Yakugakkai
Subjects
Ames test
crude drug
mutagenicity
quercetin
Sophorae flos
water extract
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Summary:Water extracts of 41 commercial crude drugs were subjected to screening studies for mutagenicity by means of the reversion assay with Ames'strain TA 98 and TA 100 of Salmonella typhimurium. Ten of the water extracts were found to be positive in the Ames test. In general, these observed mutagenicity was, however, quite weak. Among them we attempted to isolate a major mutagenic component from Sophorae flos which was markedly active, and was regarded as quercetin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0013-273X
DOI:10.1248/jhs1956.40.66